Evaluation of Efficacy of Tetracycline as a Local Drug Delivery System in the Treatment of Chronic Periodontitis as an Adjunct to Scaling and Root Planing – A Clinical and Microbiological Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 5
Abstract
Introduction: Tetracycline and its derivatives has shown to be highly effective in the treatment of chronic periodontitits. Since there are very limited microbiological study conducted to evaluate the efficacy of tetracycline fibers as a local drug therapy, the study has been taken up to evaluate the efficacy of locally delivered tetracycline fibers (Periodontal AB Plus) in conjuction with scaling and root planing in the treatment of chronic periodontitis in the patients who are not willing to undergo periodontal flap surgery. Material and methods: The present study is a randomized clinical trial with split mouth design in which a total no.of 35 patients who were diagnosed with generalized chronic moderate periodontitis, consisting of both genders (Male : Female =16 : 19), aged between 25 to 60 years were selected. These selected sites were randomly divided into test group and control group Test group - included 35 sites that were selected for the placement of Periodontal Plus AB; Tetracycline fibers (local drug delivery) after scaling and root planing. Control group - included 35 sites that were treated with scaling and root planing alone (without local drug delivery).Clinical parameters taken were the PI, GI, SBI, probing depth (PD), and clinical attachment level (CAL). Anaerobic culture was done to compare the total colony forming unit before and after the treatment. Clinical parameters were assesed at base line, 30 days and 90 days whereas the total count was calculated at baseline, 30 days and 90 days. Result: Results showed a significant improvement in all the clinical parameters. There was significant decrease in mean probing depth from base line to 90 days, and also there was significant gain in CAL in the test group as compared to control group. There was a significant reduction in the total colony count from base line to 21 days in both the group, but more reduction was observed in the test group. After 21 days to 90 days there was significant increase in the total colony count in both the group, but less increase was observed in test group. Conclusion: Within the limits of this study and on the basis of the clinical and microbiological parameters, it can be concluded that tetracycline fiber therapy enhances the benefits of SRP in the treatment of chronic periodontitis.
Authors and Affiliations
Nitesh Kumar Sharma, Anushree Prasad
Keywords
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