EVALUATION OF EFFICIENCY OF ENDOCRINE OPHTHALMOPATHY TREATMENT
Journal Title: Журнал Гродненского государственного медицинского университета - Year 2018, Vol 16, Issue 5
Abstract
Background. The achievements of modern medicine contribute to the timely diagnosis of endocrine ophthalmopathy (EOP). However, treatment continues to be a complex task, the results of which do not satisfy the physician and the patient. Purpose of the study – to evaluate the effectiveness and safety of pulse therapy with methylprednisolone in the treatment of active forms of endocrine ophthalmopathy. Material and methods. The analysis of the efficacy of treatment of 36 patients with moderate intensity of pulsed EEG by methylprednisolone therapy was carried out. The minimum cumulative dose of the drug was 4.5 grams. Results. Reduction of the activity of the image intensifier on the CAS scale and reduction of the intensity of inflammatory changes in soft tissues of the orbit was observed 1 month after the start of the drug administration. After the abolition of pulse therapy, the positive effect was preserved in 29 of 36 positively responding patients, which was 80.6%. Deterioration of the course of ophthalmopathy at the end of the course of treatment was recorded in 7 patients (19.4%), of which tobacco smoking was noted in 5 (71.4%) patients, the hormone condition was not stable in 2 (28.65%) patients, who required correction by endocrinologist. Conclusions. The therapy used enabled to reduce the inflammatory process in the orbit within a short period of time, and the subsequent scheme of the drug administration improved the effect and created a long-term remission. To treat patients with EOC in order to provide a therapeutic effect, it is necessary to use the safest doses of glucocorticoids. The definition of the prescribed therapy should be based on the degree of severity and activity of the process.
Authors and Affiliations
Zh. Krinets, V. Krasilnikova, O. Dudich
Keywords
Related Articles
- EP ID EP412280
- DOI 10.25298/2221-8785-2018-16-5-576-580
- Views 100
- Downloads 0
TOTAL EXTRAPERITONEAL INGUINAL HERNIA REPAIR IN PATIENTS WITH OBESITY
Aim. To study the effect of overweight and obesity in totally extraperitoneal repair of unilateral inguinal hernia. Material and methods. The patients were divided into group I – 24 (50%) patients with overweigh, and gr...
УСПЕШНАЯ ЭМБОЛИЗАЦИЯ СЕЛЕЗЕНОЧНОЙ АРТЕРИИ ПРИ ЛЕЧЕНИИ РЕЦИДИВИРУЮЩЕГО КРОВОТЕЧЕНИЯ ИЗ ВАРИКОЗНО РАСШИРЕННЫХ ВЕН ЖЕЛУДКА ПРИ ЛЕВОСТОРОННЕЙ ПОРТАЛЬНОЙ ГИПЕРТЕНЗИИ
Введение. Левосторонняя портальная гипертензия (ЛПГ) относится к редким причинам кровотечений. Цель. Анализ результатов выполнения рентгенэндоваскулярной эмболизации селезеночной артерии (РЭСА) при рецидивирующих кровоте...
МИНИИНВАЗИВНАЯ ХИРУРГИЯ ПРОЛАПСА МИТРАЛЬНОГО КЛАПАНА
Пролапс митрального клапана является одной из наиболее частых причин оперативной коррекции митрального клапана. С января 2013 г. по апрель 2016 г. одним хирургом прооперированы 59 пациентов по поводу недостаточности мит...
DAMAGE TO THE DUODENUM: ISSUES OF DIAGNOSTICS AND SURGICAL TREATMENT
Injuries of the duodenum can arise as a result of the action of a variety of factors and differ by localization and the extent of its damage. Diagnosis of injuries of the duodenum, especially of retroperitoneal ones, is...
DIAGNOSTICS OF SUBCLINICAL PROGRESSION OF MULTIPLE SCLEROSIS
Background. Multiple sclerosis (MS) refers to inflammatory degenerative diseases involving autoimmune mechanisms in the pathogenesis of the demyelinating process in the central nervous system. The atrophic process in the...