EVALUATION OF EZENUS IN AN EXPERIMENTAL MODEL OF DIET-INDUCED ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER CONDITION IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: Alcoholic and non-alcoholic fatty liver disease are found to affect more than 10% of the general population. Fatty liver condition in humans is directly correlated with psychosocial stress. Herbal formulations for the management of stress may present an alternative for the treatment of fatty liver disease. Ezenus is a polyherbal candy containing herbs that can ameliorate stress and consequent liver abnormality. The present study aimed to evaluate the effect of Ezenus in experimentally induced alcoholic and non-acloholic fatty liver condition.Methods: Two models were studied simultaneously, prophylactic and therapeutic. Prophylactic groups received Ezenus along with fatty diet whereas the therapeutic groups received Ezenus only after induction of alcoholic or non-alcoholic fatty liver condition. Biochemical parameters were estimated in the serum on Days 0, 45 and 90. Lipid biochemistry of liver and histopathology were performed after terminal necropsy.Results: Fatty liver condition was induced in rats within 45 days of fatty diet administration with or without alcohol. Results of the present study suggested that prophylactic administration of Ezenus prevented the development of fatty liver condition in rats to a certain extent. Therapeutic intervention with Ezenus after fatty diet intake for 45 days was able to prevent the deranging effects of fatty liver disease. This beneficial effect of Ezenus was attributed to the adaptogenic and antioxidant effects of the ingredients present in Ezenus.Conclusion: Based on the results of the study, it was concluded that long term treatment of Ezenus exhibits a preventive effect in fatty liver disease. It not only protects the liver from toxic insults to a certain extent but also has the capability of maintaining the normal liver function.Â
Authors and Affiliations
Vinoth Km Khandelwal, Prabhakar Singh, Tatiana Ravingerova, Manu Chaudhary
Keywords
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