FORMULATION AND EVALUATION OF TOPICAL PENTOXIFYLLINE-HYDROXYPROPYL METHYLCELLULOSE GELS FOR WOUND HEALING APPLICATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objectives: Oral pentoxifylline shows modest, non-significant effect on the healing rates of chronic wounds. The present research aimed to formulate topical pentoxifylline-hydroxypropyl methylcellulose (HPMC) gels and evaluate their physico-chemical properties, in vitro release characteristics and in vivo wound healing effects.Methods: Six gel formulations containing pentoxifylline (F1-F6) were prepared using HPMC with varying grades and concentrations. The physicochemical properties of gel formulations were evaluated in term of drug content, spreadability, rheological properties, swelling, and release characteristics. The efficacy of optimized formulation was further evaluated using in vivo excision wound models in rats.Results:Â The spreadability, flow index and swelling percentage of gel formulations ranged 10.71-12.24 gcm/sec, 0.33-0.91 and 148.61-8011.61%, respectively. The rheological study of the prepared formulations exhibited pseudoplastic behavior, which is a characteristic feature of topical gels. Swelling results of F5 and F6 deduced that the cross-linked structures were formed between the polymeric chains. The in vitro drug release profiles of all formulations were found to be followed Higuchi model. The in vivo evaluation performed using rat excision wound model showed significant difference (P < 0.05) in the percentage reduction of wound size between treatment and control groups. The treatment group exhibited complete healing by day 13 as compared with day 15 in the control group.Conclusions:Â These findings indicated that F5 gel formulation had demonstrated effective release profile for pentoxifylline. The in vivo results confirmed that F5 has pronounced wound healing effects when employed topically.Â
Authors and Affiliations
Rafaella Siang, Siew Yong Teo, Siang Yin Lee, Arun Kumar Basavaraj, Rhun Yian Koh, Michael John Rathbone
Keywords
Related Articles
- EP ID EP579633
- DOI -
- Views 118
- Downloads 1
ETHANOL-INDUCED ALTERATIONS IN CARDIAC ENZYMES–AMELIORATIVE EFFECT OF THESPESIA POPULNEA LEAF EXTRACT
Objective: This study covers the estimation of changes in cardiac enzymes such as ATPases and antioxidant enzymes following ethanol-administration in rats, and the possible ameliorative effect of leaf extract of the plan...
CARDIOPROTECTIVE EFFICACY OF TAURINE ON LIPID-METABOLISM OF ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION
Objective: The present study aimed to evaluate the effect of pre-treatment with taurine on rats in which MI had been induced using isoproterenol (ISO).Methods: Rats were randomly allocated into three groups; the 1st grou...
FORMULATION AND CHARACTERIZATION OF CARVEDILOL NANOEMULSION ORAL LIQUID DOSAGE FORM
Objective: Carvedilol is antihypertensive. It is practically water insoluble. Therefore, the objective of this investigation is a formulation and characterization of carvedilol nano emulsion (NE) employing orally to incr...
IN SILICO STUDY FOR IDENTIFICATION OF DRUG LIKE INHIBITOR FROM NATURAL COMPOUNDS AGAINST INHA REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS
Objective: Natural products have played an important role for developing new drugs and becoming popular due to toxicity and side effects of allopathic medicine. The main objective of this research work is to find drug-li...
SURVEY BASE STUDY ON CURRENT TREND OF TREATMENT OF COMMUNITY-ACQUIRED PNEUMONIA IN KARACHI
Objective: Community-acquired pneumonia (CAP) is a potentially serious infection that results in various general physicians (GP) visits and hospital admission every year. The prime objective of this research was to find...