FORMULATION AND CHARACTERIZATION OF CARVEDILOL NANOEMULSION ORAL LIQUID DOSAGE FORM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 12
Abstract
Objective: Carvedilol is antihypertensive. It is practically water insoluble. Therefore, the objective of this investigation is a formulation and characterization of carvedilol nano emulsion (NE) employing orally to increase carvedilol solubility for enhancing of carvedilol bioavailability.Methods: The formulation components were chosen according to the solubility study. The diagrams of pseudo-ternary phase were made using the aqueous phase titration method. The formulated nanoemulsions were subjected to various thermodynamic stability assays. We selected eight of formulas that have thermodynamic stability for further optimization for various characterizations in order to select the best formula.Results: The carvedilol NE3 considered a selected formula. It composes of 1.25 mg carvedilol per g of the nanoemulsion, 10 % of peppermint oil, 20% of tween80, 10% ethanol and 60% of distilled water. It was characterized by a low globule size range, low poly dispersity index, higher zeta potential, good pH value, efficient electroconductivity, classy percent of light transmittance, higher % drug content, acceptable low viscosity and carvedilol release was significantly higher (P<0.05) in dissolution rate. The carvedilol NE3 subject for further investigations. Fourier transformed infrared spectroscopy confirm no incompatibility between the drug and excipients. The atomic force microscopy study shows that system in nanoscale and has high stability.Conclusion: The selected formula (carvedilol NE3) was a promising nanoemulsion formula that increases the carvedilol solubility result in an increment of its bioavailability.Â
Authors and Affiliations
Hayder Kadhim Drais, Ahmed Abbas Hussein
Keywords
Related Articles
- EP ID EP578057
- DOI -
- Views 47
- Downloads 0
FORMULATION AND EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF PROPRANOLOL HYDROCHLORIDE
Objective: The present study was to formulate and evaluate of sustained release bilayer tablets of anti-hypertensive drugs propranolol hydrochloride.Methods: The tablets were prepared by direct compression method by usin...
EXTRACTION OF A WATER SOLUBLE BIOACTIVE HYPOXOSIDE AND ITS DEVELOPMENT INTO AN ETHOSOMAL SYSTEM FOR DEEP DERMAL DELIVERY
Objective: This study was aimed to extract Hypoxoside, a water soluble phytochemical, from the corms of Hypoxis hemerocallidea, and incorporate it into a suitable transdermal carrier system to increase its penetrability...
DETERMINATION AND CHARACTERIZATION OF PROCESS IMPURITIES IN PAZOPANIB HYDROCHLORIDE DRUG SUBSTANCE
Objective: To develop a rapid, sensitive, accurate, precise and linear Reverse-Phase High-Performance Liquid Chromatographic (RP-HPLC) method and validate as per ICH guidelines for the quantitative estimation of Pazopani...
DOCUMENTATION OF TRIBAL CLAIMS FOR RHEUMATISM IN ODISHA, INDIA
Objectives: Odisha has been known as a rich source of valuable medicinal plants. Present work enumerates the indigenous knowledge on plant utilized as a natural remedy for rheumatism by the local or native peoples of Odi...
SPECTROPHOTOMETRIC, HPTLC AND GC-MS STUDIES ON SELECTED SPICE EXTRACTS
Objectives: The present work was carried out with a view to analyze the major phytochemical compounds of Indian spices, cumin (Cuminum cyminum L.), fenugreek (Trigonella foenum-graecum L.) and fennel (Foeniculum vulgare...