EVALUATION OF HAEMORHEOLOGICAL PARAMETERS AND ATHEROGENIC INDEX OF PLASMA AND CASTELLI RISK INDICES OF APPARENTLY HEALTHY ADULTS IN PORT HARCOURT, NIGERIA
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 5
Abstract
Aims: Evaluation of lipoprotein profile, atherogenic ratios and haemorheological parameters as indicators and significant adjuncts for predicting atherosclerosis in an apparently healthy population was investigated. Methodology: A total of 300 subjects comprising 169 (56.3%) males and 131 (43.7%) females within the age range of 18-45 were recruited into the study. Haemorheological parameters such as haemoglobin, haematocrit, erythrocyte sedimentation rate, platelets, fibrinogen, whole blood viscosity and plasma viscosity were determined using standard methodologies. Fasting lipid profile parameters were assessed using standard procedures. Results: Results of the lipoprotein determinations were used to calculate the atherogenic indices namely Atherogenic Index of Plasma, and Castelli Risk Index I and II. Analysis of variance and student t-test were used to compare the means of the parameters. ANOVA analysis of the means of the haemorheological parameters showed no significant difference (p>0.05) in the means of the haemorheological parameters between the age classes except for fibrinogen (p<0.05). However, significant differences (p<0.05) in means of the lipoproteins were observed between the age classes except for triglycerides. Comparison of the means of the haemorheological parameters between the male and female subjects showed significant difference (p<0.05) for all parameters except platelets whereas no significant difference (p>0.05) was observed in the means of the lipoproteins levels and the atherogenic indices between the male and female subjects. Conclusion: Analysis of the haemodynamic parameters, the lipoprotein profiles and the atherogenic risk of the population for predisposition and development of cardiovascular disease events and atherosclerosis in the absence of risk factors such as cigarette smoking, hypertension, and diabetes mellitus did not reveal risk in the subjects.
Authors and Affiliations
Ebirien-Agana S. Bartimaeus
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