EVALUATION OF HEAVY METAL DISTRIBUTION AND ANTIBACTERIAL ACTIVITIES OF MEDICINAL PLANTS TINOSPORA CORDIFOLIA, OCIMUM SANCTUM AND PIPER NIGRUM
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2014, Vol 6, Issue 3
Abstract
To evaluate the inhibition and the in vitro interaction of the pathogens with the plant extracts, various solvent extracts of Tinospora cordifolia, Ocimum sanctum, Piper nigrum were screened for antimicrobial activity using agar well diffusion method. A synergistic inhibitory activity by the combination of aqueous extracts of the three plants against Salmonella, Shigella and P. aeruginosa was observed. The chloroform extracts in combination also showed maximum inhibition against E. coli but ethanolic extract in equimolar concentration showed maximum inhibition against Staphylococcus aureus. All these plant extracts were tested for heavy metal (HM) content as they are often contaminated during the growth, development and processing. O. sanctum and P. nigrum contained the maximum HM content while T. cordifolia contained less HM. The plants extracts in combination also showed low contamination with heavy metal which is a positive indication for their potential use in combating infections. These results indicate that plant extracts in combinations are less contaminated with heavy metals but they are very potent in fighting emerging pathogens.
Authors and Affiliations
M Debnath, P Lal, R Jain
Keywords
Related Articles
- EP ID EP625023
- DOI -
- Views 50
- Downloads 0
ANTI ARTHRITIC ACTIVITY OF CAESALPINIA PULCHERRIMA AGAINST TYPE II COLLAGEN INDUCED ARTHRITIS IN EXPERIMENTAL RATS
Caesalpinia pulcherrima is a medicinal plant belonging to the family Caesalpiniaceae. The main aim of the present study was to investigate the Anti Arthritic activity of the ethanolic extract of Caesalpinia pulcherrima (...
IN VITRO ANTIBACTERIAL POTENTIAL OF HALOPHILIC BACTERIAL SECONDARY METABOLITES FROM SALTED FISH
Living organisms can be found over a wide range of extreme conditions. Most of the organisms living in extreme environments (i.e, extremophiles) belong to the prokaryotes. Halophiles are interesting class of extremophili...
ACUTE TOXICITY, IN-VITRO UROLITHIATIC & DIURETIC EVALUATION OF METHANOLIC EXTRACT OF HYGROPHILA SALICIFOLIA, WHOLE HERB IN RAT
Hygrophila salicifolia (Family: Acanthaceae) is an erect herb, nearly glabrous, mainly whole herb used as raw material in medicine. The aim of present investigation was to evaluate acute toxicity, in vitro urolithiatic a...
PREPARATION AND IN VIVO EVALUATION OF SOLID DISPERSIONS USING REPAGLINIDE
In the present study, immediate release solid dispersion of Repaglinide was formulated by solvent evaporation technique. Repaglinide solid dispersions were prepared using PEG 8000, Pluronic F 127 and Gelucire 44/14 by so...
ANTIULCER ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF BETA VULGARIS, CHENOPODIACEAE
Beta vulgaris (chenopodiacea) is a medicinal plant reported for its variety of ethnic medicinal uses. Beta vulgaris showed antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and an...