Evaluation of Hematological and Biochemical Profile of Early Dengue Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 6
Abstract
Introduction: Dengue infection has been identified as the fastest spreading mosquito-borne viral disease by World Health Organization. This study is an attempt to elucidate the positive laboratory profile of serologically diagnosed early dengue patients so as to facilitate early diagnosis, treatment and management. Material and methods: A total of 100 cases diagnosed as dengue based on rapid immunological card tests (NS1 antigen and Ig M antibodies) were analyzed for haematological and biochemical parameters. Haematological parameters included haemoglobin, hematocrit, TLC, DLC, platelets count and peripheral blood smear. Biochemical parameters including serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total Bilirubin (T. Bil.) and Alkaline phosphatase (ALP). Result: Haemoglobin ranged from 6.4-17.0 gm/dl. Hematocrit was raised in 06 (06%) cases. Thrombocytopenia (Platelets count <1lakh/mm3) was seen in 54 (54%) cases. TLC <4,000/ mm3 was seen in 43 (43%) cases and >11,000/mm3 was seen in 09 (09%) cases. Lymphocytosis and neutrophilia were seen in 40 (40%) and 14 (14%) cases respectively. On peripheral blood smear reactive and plasmacytoid lymphocytes seen. AST, ALT, ALP and Bilirubin were deranged in 64 (64%), 60(60%), 12(12%) and 02(02%) cases respectively. Conclusion: Haemoconcentration, leucopenia, thrombocytopenia, lymphocytosis, and raised liver enzymes SGOT and SGPT along with reactive/ plasmacytoid lymphocytes on peripheral smear gives enough clues to test for dengue serology so that dengue cases can be diagnosed in their initial stages and prompt management can be started to prevent complications of dengue fever.
Authors and Affiliations
Gitika . , Monika Garg, Gurtej Singh Gill
Keywords
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