EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC SEED EXTRACT Cicer arietinum AGAINST CCL4 INDUCED HEPATOTOXICITY ALBINO RATS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 6
Abstract
The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Cicer arietinum seeds against CCl4 induced albino rats. The ethanolic extract of Cicer arietinum was administered orally to the animals with hepatotoxicity induced by CCl4 (0.5ml/kg i.p. with Arachis oil). Silymarin (100 mg/kg) was used in the present study as standard drug for one group. The two doses of Ethanolic seed extract of Cicer arietinum (250kg/kg and 500mg/kg p.o) were used in this evaluation. The plant extract was effective in protecting the liver against the injury induced by CCl4 in rats. This was evident from significant reduction in serum glutamic-pyruvic transaminase (SGPT), serum glutamic oxalo acetic transaminase (SGOT), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the hepatoprotective activity of ethanolic extract of Cicer arietinum seeds against CCl4 induced hepatotoxicity in rats.
Authors and Affiliations
S. DIVYA TEJA. BANDA*| Department of Pharmacology, Sri Sai Aditya Institute of Pharmaceutical Sciences & Research, Surampalem, East Godavari Dist. Andhra Pradesh, India., K. SANTHOSHI| Department of Pharmacology, Sri Sai Aditya Institute of Pharmaceutical Sciences & Research, Surampalem, East Godavari Dist. Andhra Pradesh, India., V. RAVI KUMAR| Albino research and Training Institute, Bachupally, Hyderabad, India.
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