EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC SEED EXTRACT Cicer arietinum AGAINST CCL4 INDUCED HEPATOTOXICITY ALBINO RATS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 6
Abstract
The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Cicer arietinum seeds against CCl4 induced albino rats. The ethanolic extract of Cicer arietinum was administered orally to the animals with hepatotoxicity induced by CCl4 (0.5ml/kg i.p. with Arachis oil). Silymarin (100 mg/kg) was used in the present study as standard drug for one group. The two doses of Ethanolic seed extract of Cicer arietinum (250kg/kg and 500mg/kg p.o) were used in this evaluation. The plant extract was effective in protecting the liver against the injury induced by CCl4 in rats. This was evident from significant reduction in serum glutamic-pyruvic transaminase (SGPT), serum glutamic oxalo acetic transaminase (SGOT), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the hepatoprotective activity of ethanolic extract of Cicer arietinum seeds against CCl4 induced hepatotoxicity in rats.
Authors and Affiliations
S. DIVYA TEJA. BANDA*| Department of Pharmacology, Sri Sai Aditya Institute of Pharmaceutical Sciences & Research, Surampalem, East Godavari Dist. Andhra Pradesh, India., K. SANTHOSHI| Department of Pharmacology, Sri Sai Aditya Institute of Pharmaceutical Sciences & Research, Surampalem, East Godavari Dist. Andhra Pradesh, India., V. RAVI KUMAR| Albino research and Training Institute, Bachupally, Hyderabad, India.
Keywords
Related Articles
- EP ID EP2359
- DOI -
- Views 373
- Downloads 24
A STUDY FOR LINGUAL NERVE PROTECTION DURING EXTRACTION OF THIRD MOLAR USING LINGUAL REACTOR
Lingual nerve damage during surgical removal of third molar is most common nerve damage reported. Its incidence rate has been reported from 0.6 to as high as 22% in various studies conducted. Our aim was to study the eff...
Pharmacognostical and Phytochemical Investigation of Alternanthera Bettzichiana (Regel) Nicols.
The present study reveals the macroscopical, microscopical and preliminary phytochemical investigation of Alternanthera bettzichiana (Regel) Nicols. Very scanty reports are available on microscopical and phytochemical st...
DESIGN AND DEVELOPMENT OF EUDRAGIT COATED CHITOSAN MICROSPHERES FOR COLON TARGETED DELIVERY
Oral route is the most convenient and preferred route but other routes for CDDS may be used. Rectal administration offers the shortest route for targeting drugs to the colon. However, reaching the proximal part of colo...
ARTERIAL VARIATIONS OF HUMAN SUPRARENAL GLAND- A CASE REPORT
Knowledge of anomalous arteries to the suprarenal gland (SRG) is significant for surgeons and intervention radiologists. These variations cannot be ignored. During routine dissection in male cadaver, following variation...
SEROPOSTIVITY OF TRANSFUSTION TRANSMISSIBLE HIV INFECTIONS AMONG VOLUNTARY AND REPLACEMENT BLOOD DONORS
Background: The evaluation of the data of the prevalence of transfusion transmissible infections (TTI) among blood donors permits an assessment of the acqisition of the infections in the blood donor population and conseq...