DESIGN AND DEVELOPMENT OF EUDRAGIT COATED CHITOSAN MICROSPHERES FOR COLON TARGETED DELIVERY
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 6
Abstract
Oral route is the most convenient and preferred route but other routes for CDDS may be used. Rectal administration offers the shortest route for targeting drugs to the colon. However, reaching the proximal part of colon via rectal administration is difficult. Rectal administration can also be uncomfortable for patients and compliance may be less than optimal. Administration of glucocorticoids namely dexamethasone by oral route produce systemic side effects including adenosuppression, immunosuppression, cushinoid symptoms, and bone resorption. Thus selective delivery of drugs to the colon could not only lower the required dose but also reduce the systemic side effects caused by high doses. The aim of the present investigation was to prepare colon targeted microspheres of Dexamethasone using a combination of time and pH dependent polymer that offer protection to the drug until it leaves the stomach which is provided by pH dependent polymethacrylate polymer, Eudragit S 100 and major drug release in small intestine is avoided by providing pH independent coating of Chtosan. For preparation of colon targeted microspheres the Microspheres of dexamethasone were first prepared with pH independent polymer Chitosan then with outer layer of a pH dependent polymer Eudragit L100.
Authors and Affiliations
Srikant Bhaargava*| TIT College of Pharmacy, Bhopal, Mithun Bhowmick| TIT College of Pharmacy, Bhopal, Girijesh Kumar Pandey| TIT College of Pharmacy, Bhopal, Amit Joshi| TIT College of Pharmacy, Bhopal, Balkrishna Dubey| TIT College of Pharmacy, Bhopal
Keywords
Related Articles
- EP ID EP2355
- DOI -
- Views 393
- Downloads 25
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF LEVOSULPIRIDE AND PANTOPRAZOLE IN TABLETS BY RP-HPLC METHOD
A simple, precise, accurate, rapid and economical reverse phase high-pressure liquid chromatographic method has been developed as per ICH norms for the simultaneous estimation of Levosulpride and pantoprazole sodium from...
Therapeutic effect of quercetin on the complications of nicotinamide-streptozotocin induced type-2 diabetes in male rats
Introduction: Type-2 diabetes mellitus (T2DM) is a rapid growing epidemic disease, with a continually increasing prevalence that exhibit complications in different body organs. The nicotinamide-streptozotocin (NA-STZ) ra...
Immunological exploration of virally infected and non-infected leaves of Tobacco plant on human whole blood and peripheral blood mononuclear cells
Introduction- Virally infected plants are of great concern especially for farmers including researchers because of enormous loss and cause disease in different crops e.g. vegetables, fruits, cereals etc. In this study, o...
DIAGNOSIS OF URINARY TRACT INFECTION: FRESH URINE MICROSCOPY OR CULTURE
The study was conducted in the department of Microbiology, Nobel Medical College and Teaching Hospital, Biratnagar, to assess whether urine microscopy is effective enough to diagnose urinary tract infection or not. The...
PHAGE THERAPY: THE USE OF BACTERIOPHAGES AGAINST INFECTIONS
Phages are a kingdom of viruses that infect bacteria, and are distinct from the animal and plant viruses. Phages can have either a “lytic” or a “lysogenic” life cycle. After their discovery early in the 20th century, pha...