Evaluation of Hepatoprotective Potential of Swertia tetragona Edgew
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
This study was designed to evaluate the hepatoprotective potential of aqueous and hydroalcoholic extracts of Swertia tetragona. Both the extracts of S. tetragona showed good hepatoprotective activity against thioacetamide induced liver injury. Biochemical evidences as normalization of Serum parameters(ALP,ALT,Alkaline Phosphatase and GGT), Oxidative stress parameters(lipid peroxidation and reduced glutathione), Free radical scavengers(catalase and glutathione peroxidase), Phase II drug metabolizing enzymes(glutathione-s-transferase), Glutathione metabolizing enzymes (glutathione reductase and G-6-PD), Free radical scavengers (SOD and xanthin oxidase) and Histopathological evidences provide support to these findings.
Authors and Affiliations
Bader GN*1, Naqash A1, Mir PA, Ali S2
Keywords
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- EP ID EP390936
- DOI 10.9790/3008-1205021728
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