Evaluation of Hypolipidemic Activity of Allium schoenoprasum in Albino Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 14, Issue 5
Abstract
Aim of Study: This study was designed to evaluate the hypolipidemic action of aqueous and ethanolic extracts of leaves of Allium schoenoprasum in albino rats. Methodology: 500 g of dried leaves powder was initially soaked in 3 L of 99.9% ethanol for three days and after filtration residues was soaked in 2 L distilled water for further three days. Both filtrates were subjected to rotary evaporator to get semi solid pastes. Rats were divided in five groups with six animals in each group. Hyperlipidemia was induced in rats by intraperitoneal administration of Triton X-100 (100 mg/kg/ip). After 72 hours, normal group was given normal saline while hyperlipidemic protocols were given to other groups. 200 mg/kg/p.o dose of ethanolic and aqueous extracts were administered to the experimental groups while Atorvastatin 10 mg/kg/p.o was given to standard control groups for 7 days. At 8th day blood sample was collected and serum samples were analyzed for biochemical parameters i.e. total serum cholesterol, serum triglycerides, HDL, LDL and VLDL level. Results: %age yield of ethnolic extract was 17% and for aqueous extract it was 9%. 113±3.3, 105±5.7, 29±1.3, 102±2.0 and 27±1.1 mg/dl were level of serum cholesterol, triglycerides, HDL, LDL and VLDL respectively, observed in ethanolic extract treated rats while aqueous extract treated rats showed 111±2.0, 103± 2.2, 24±0.88, 102±1.1 and 27±0.95 mg/dl, respectively which were significantly (P < .001) different from disease controlled group. Results indicate significant reduction in the levels of total serum cholesterol, triglycerides, LDL and VLDL while level of HDL was significantly elevated in the experimental control groups. Conclusion: All investigations indicated that Allium schoenoprasum dried leave extracts have potential to cause hypolipidemia.
Authors and Affiliations
Aamir Mushtaq, Shazma Farhat Naqvi, Rukhsana Anwar, Mehwish Jamil, Habib Anwar, Asifa Bashir, Qurat-ul-Ain . , Baderqa tul Ayesha
Keywords
Related Articles
- EP ID EP342333
- DOI 10.9734/BJPR/2016/31804
- Views 88
- Downloads 0
Pharmaceutical Quality Analysis of Ceftriaxone Sodium Brands Marketed in Southern Nigeria
One of the paramount controversies between Physicians and Pharmacists is the issue of generic substitution. Prescribers are compelled to choose from such a large range of brands. The objective of this study was to compar...
In silico Identification of Novel Potential BACE-1 Inhibitors for Alzheimer’s Disease Treatment: Molecular Docking, Pharmacophore Modeling and Activity and Synthetic Accessibility Predictions
Aims: Alzheimer's Disease (AD) is a progressive neurodegenerative disease accompanied by loss of memory and cognition. With its causes still unknown, one of the main hypotheses related to its pathogenesis is the amyloida...
Survey on Antimicrobial Resistance: Reason behind the Misuse of Antibiotics in Bangladesh
Aims: It is a base line survey to find the reason behind the misuse of antibiotic in Bangladesh. Study Design: Questionnaires were supplied to corresponded persons to collect information from patient, doctors & pharmacy...
Screening of Pharmacognostical, Phytochemical Profile and Traditional Application of Ficus benghalensis
Ficus benghalensis belonging to Moraceae family is mostly familiar as “Banyan tree” or “Indian fig” with several vernacular names. Gigantic in appearance, as a colossal evergreen tree, it is extended by spreading branche...
Anti-inflammatory and Antinociceptive Effects of the Aqueous Extract of the Bark of Chrysobalanus icaco Linnaeus
Aims: This paper describes the anti-inflammatory and antinociceptive effects of the aqueous extract of Chrysobalanus icaco. Study Design: Study the anti-inflammatory and antinociceptive activity of the aqueous extract...