Evaluation of Immunomodulatory activity of the flavanoid from Kigelia africana
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of Flavanoid of Kigelia africana. The effect of flavanoid of Kigelia africana on the immune system of rats and mice was evaluated by using different experimental models such asmice lethality test, Serum immunoglobulin level, Haemagglutination reaction, hypersensitivity reaction, and delayed type hypersensitivity reaction test. Flavanoid of Kigelia africana was administered orally at low dose and high dose of 100mg/kg/day, poand 200 mg/kg/day, po respectively and Levamisole (2.5 mg/kg/day, po) was used as standard drug. Flavanoid of Kigelia africanain both doses increased the levels of serum immunoglobulin and prevented the mortality induced by bovine Pasteurella multocida in mice. Exhibits a dose related increase in the early hypersensitivity reaction and Delayed type hypersensitivity reaction to the SRBC antigen. It also resulted in a significant increase in the antibody titer value, to SRBC, in experimental animals. Hence, it was concluded that flavanoid of Kigelia africana increases both humoral immunity and cell mediated immunity.
Authors and Affiliations
PKM Nagarathna| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India, K. Reena| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India, Sriram Reddy| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India, Johnson Wesley| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India
Keywords
Related Articles
- EP ID EP14141
- DOI -
- Views 351
- Downloads 26
Evaluation of Vitamin B1, B2 and B6 Tablets in Bangladesh by UV-Vis Spectrophotometer
Thiamine hydrochloride (vitamin B1), riboflavin (vitamin B2) and pyridoxine hydrochloride (vitamin B6) were assayed in pharmaceutical dosages form. Thiamine hydrochloride of 100 mg dose of six different companies, ribofl...
Fabrication and Optimization of Novel Lornoxicam Matrix Tablets Using 3-Factor 3- Level Box-Behnken Statistical Design: Invitro and Invivo Evaluation
In the present study efforts have been made to prepare sustained release matrix tablets of Lornoxicam. Matrix tablets were prepared by direct compression method by using Hydroxypropyl methyl cellulose K15 (HPMC- K15),...
Isolation Endophytic Bacteria of Mangosteen (Garcinia mangostana L.) Skin Fruit as of Escherichia coli Antibacterial
Infectious diseases are caused by bacteria and fungi in developing countries are still high. One of the microorganisms that cause infections are Escherichia coli. E. coli can lead to infection of the digestive tract. Imp...
Gold Nanoparticles synthesis, properties, and forthcoming applications – A review
Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characte...
Cyclic Changes In The Hypothalamo Neurohypophysial System of Xenentodon Cancila (HAM.)
The presence of functional hypothalamo-hypophysial neurosecretory system in vertebrates has led to revise earlier views regarding the hypothalamus-pituitary relationship. The hypothalamo-neurohypophysial system which c...