Evaluation of Immunomodulatory activity of the flavanoid from Kigelia africana
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of Flavanoid of Kigelia africana. The effect of flavanoid of Kigelia africana on the immune system of rats and mice was evaluated by using different experimental models such asmice lethality test, Serum immunoglobulin level, Haemagglutination reaction, hypersensitivity reaction, and delayed type hypersensitivity reaction test. Flavanoid of Kigelia africana was administered orally at low dose and high dose of 100mg/kg/day, poand 200 mg/kg/day, po respectively and Levamisole (2.5 mg/kg/day, po) was used as standard drug. Flavanoid of Kigelia africanain both doses increased the levels of serum immunoglobulin and prevented the mortality induced by bovine Pasteurella multocida in mice. Exhibits a dose related increase in the early hypersensitivity reaction and Delayed type hypersensitivity reaction to the SRBC antigen. It also resulted in a significant increase in the antibody titer value, to SRBC, in experimental animals. Hence, it was concluded that flavanoid of Kigelia africana increases both humoral immunity and cell mediated immunity.
Authors and Affiliations
PKM Nagarathna| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India, K. Reena| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India, Sriram Reddy| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India, Johnson Wesley| Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India
Keywords
Related Articles
- EP ID EP14141
- DOI -
- Views 330
- Downloads 26
Nelumbo Nucifera (Lotus): A Review on Ethanobotany, Phytochemistry and Pharmacology
Nelumbo nucifera Gaertn (Nymphaeaceae), a perennial aquatic plant, has been used as a medicinal herb in China and India. It has been recorded in the most famous medicinal book in China for more than 400 years. Different...
Gold Nanoparticles synthesis, properties, and forthcoming applications – A review
Gold nanoparticles (AuNPs) have several biomedical applications in diagnosis and treating of disease such as targeted chemotherapy and in pharmaceutical drug delivery due to their multifunctionality and unique characte...
Mineral contents from some fabaceous plant species of Rajasthan desert
Evaluation of mineral contents from three selected plant species of Fabaceae family growing in arid region of Rajasthan Desert was carried out. The roots, shoots and fruits of Clitoria ternatea, Sesbania bispinosa and...
Berberis lycium a Medicinal Plant with Immense Value
Berberis lycium belong to family Berberidaceae is an evergreen shrub growing in Himalayan region. The various parts of the plant like root, bark, stem, leaves and fruits are used by the people as a medicine or food. Th...
Antimicrobial potential of the marine intertidal sponge, Ircinia fusca from west coast of India
In vitro antimicrobial screening of marine sponge (Porifera) Ircinia fusca collected from west coast of India, against selected bacteria and fungi was conducted in this study. Crude sponge extracts of the marine organi...