Evaluation of Kinetic Effects of Baicalein in Different Breast Cancer Cell Lines
Journal Title: Cumhuriyet Science journal - Year 2019, Vol 40, Issue 1
Abstract
The aim of this study was to compare the antiproliferative effects of baicalein which is a flavonoide on MCF-7 and MDA-MB-231 cell line. The experiments were carried out with the evaluation of the parameters. Including cell viability, cell index, mitotic index, labelling index and apoptotic index. With the cell viability test, IC50 concentrations of baicalein for MCF-7 and MDA-MB-231 cells were determined as 10 µM and 30 µM, respectively and these concentrations were used in all experiments. The results showed that the IC50 concentrations decreased the values of cell viability, cell index, mitotic index and labelling index and increased the apoptotic index value for both cell types. These decreases and increases are statistically significant (p<0.01). In addition, curves of the graphs obtained from the xCelligence Real-Time Cell Analysis System showed that baicalein has cytoskeletal effects on MCF-7 cells and cytostatic effects on MDA-MB-231 cells. The results obtained from this study suggest that baicalein can be used in patients with luminal A and triple negative breast cancer in the clinic by supporting the future studies due to its antiproliferative effects on MCF-7 and MDA-MB-231 cells.
Authors and Affiliations
Mehmet Rıfkı TOPÇUL
Keywords
Related Articles
- EP ID EP488277
- DOI 10.17776/csj.511141
- Views 48
- Downloads 0
A Computational Study of 1-substituted methyl 9-methyl-9H-pyrido[3,4-b]indole-3-carboxylate: Quantum Chemical Descriptors, FMO and NBO Analysis
This work dealt with the investigation of the methyl 9H-pyrido[3,4-b]indole-3-carboxylate (Basic compound) and its C1-substituted derivatives to search for the best substituent group that enhances the chemical reactivity...
Influences of Cerium Addition on the Structural and Superconducting Properties with Pb and Pb-free Bi2Sr2Ca2Cu3Oδ System
In this study, the thermal, structural and superconducting properties with lead and lead-free cerium added Bi2Sr2Ca2Cu3Oδ superconducting system have been investigated. Cerium-added superconductors with the general stoic...
Çoklu-İlaç Dirençli P. aeruginosa ve E.coli Suşlarında Antibiyotik Direnç Genlerinin ve Sınıf 1 İntegron Gen Kasetlerinin Araştırılması
P. aeruginosa ve E.coli izolatlarının birçok antibiyotiğe direnç kazanması nedeniyle bu patojenlerin neden olduğu enfeksiyonların tedavisi zorlaşmıştır. Bundan dolayı klinik izolatlarda antibiyotik direnç genlerinin beli...
Determination of the Genotoxicity of the Soil in the Aydın Region Irrigated by Büyük Menderes River by the Allium Test System
Nowadays, one of the most important problems is environmental pollution. Environmental pollution in the Büyük Menderes River-basin, which is one of the agricultural fields in Turkey, has reached important dimensions. B....
The Investigation of Mechanical Properties of the Flash Welded Different Steel Bars
In this study, three type steel bars were selected as experimental specimens. The steel types are S235JR (St37), S355JR (St52), AISI 304 stainless steel. Experimental parameters are material type and weld current. The sp...