Evaluation of Lipid Profile in Patients with Liver Cirrhosis
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Liver plays a vital role in lipid metabolism. It contributes both in exogenous and endogenous cycles of lipid metabolism and transport of lipids through plasma. Frequently multiple etiological factors contribute to the development of cirrhosis, as exemplified in epidemiological studies that identified regular (moderate) alcohol consumption, age above 50 years, and male gender as risk factors in chronic hepatitis. Due to the high prevalence of chronic liver disease in our country, we conducted this study to determine lipid profile in patients with cirrhosis. Material and methods: The present study was conducted in the Department of Medicine, Govt. Medical College, Patiala on 100 patients with liver cirrhosis and 50 age, sex matched healthy controls, who were admitted to medical wards during the period of study. Then they were subjected to detailed history taking, clinical examination and relevant investigations as per case requirement using a Performa specially designed for this study. All the data was arranged in a tabulated form and analysed using SPSS software. Student t test was used as a test of significance. Probability value of less than 0.05 was regarded as significant. Results: Mean total cholesterol in cirrhotic study group was 147.29+17.14 and in control group was 163.86+17.63. Mean VLDL cholesterol in cirrhotic study group was 24.11+4.05 and in control group was 27.1+3.65. In cirrhotic group, there were 86 males and 14 females out of 100. In control group, 40 were males and 10 were females out of 50. Conclusion: Our study concluded that there is decrease in lipid profile parameters in cirrhotic patients, more severe the cirrhosis, there is greater fall in lipid profile parameters.
Authors and Affiliations
Satish Sachdeva, Jaswinder Singh, Ashish Kumar, Jasvir Singh, Rajiv Aggarwal, Gourav Bansal
Keywords
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