Evaluation of Lipid profile levels in acne vulgaris on low dose isotretinoin: A prospective study
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 4
Abstract
Aim: The present study is to assess the effect on the variations of total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol in patients with acne vulgaris on low dose isotretinoin treatment. Materials and Method: A total of fifty patients diagnosed having moderate to severe acne with the age group of 15-45yrs attending dermatology department, was treated with 20mg of isotretinoin daily for 4 months. Blood Samples were collected on day 0, 2nd wk, 1month, 2month, 3month and 4month. Result: Measured baseline values of cholesterol in continuous therapy group 116.86 ± 23.55, then after at 4wks, 8wk, 12wk, 16wk and at the end of the treatment were increased above the baseline values at every interval. Significant P-value is obtained when compared with the baseline. There was statistically significant increase in cholesterol, triglycerides, LDL at all the intervals compared with baseline and above normal limit with significant decrease in HDL levels. Conclusion: Low dose continuous isotretinoin therapy caused increase in cholesterol, triglycerides, LDL above the normal range with grade 1 increase and decrease in HDL levels. Side effects were mild and well tolerated and did not need termination of the treatment. However it is important to educate about the consequences. We advise our specialist that the usage of low dose isotretinoin in moderate to severe acne can be done with minimal concern but close follow up is important.
Authors and Affiliations
Leelambika C, Pushpa Sarkar
Keywords
Related Articles
- EP ID EP297926
- DOI 10.18231/2394-6377.2017.0083
- Views 83
- Downloads 0
Role of cancer antigen 125 and risk of malignancy index 3 to differentiate benign and malignant female pelvic masses followed by histopathological correlation
Introduction: Pelvic mass is a worldwide female health problem with serious consequences in mortality, morbidity, and cost to the society. The present study was designed to see the role of serum Cancer Antigen 125 (CA125...
Assessment of Vitamin D status in Type 1 Diabetes Mellitus in pediatric age group
Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Type-1-Diabetes Mellitus (TIDM) results from autoimmune destruction of beta cells leading to insulin deficiency. Vitamin D d...
A case control study of stress and infertility in hypothyroid reproductive age group women residing in Udaipur, Rajasthan, India
Introduction: Challenges to human being fertility may occur from numerous conditions caused through hereditary abnormalities, communicable or else environmental agents, as well as certain behaviors. Reproduction is one o...
Biochemical markers for early senescence of erythrocyte membrane in type 2 diabetes mellitus
Diabetes mellitus is an ice berg of disease resulting due to impairments in insulin secretion insulin action or both Hyperglycemia caused due to the above defects leads to complications like neuropathy nephropathy retino...
Methylenetetrahydro folatereductase enzyme polymorphism associated with hyperhomocysteinemia in patients with stroke
Cerebrovascular stroke is complex heterogeneous multifactorial disorder associated with number of risk factors, including diabetes mellitus,hypertension, tobacco smoking or chewing; etc. MethylenetetrahydroFolate reducta...