Biochemical markers for early senescence of erythrocyte membrane in type 2 diabetes mellitus
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 3
Abstract
Diabetes mellitus is an ice berg of disease resulting due to impairments in insulin secretion insulin action or both Hyperglycemia caused due to the above defects leads to complications like neuropathy nephropathy retinopathy peripheral vascular disease and coronary artery disease as a result of stimuli for oxidative stress on cellmembrane The aim of the study is to establish a relation between the stress induced by oxidants bringing changes with the erythrocyte membrane The protein content protein thiols protein carbonyl levels in relation to control of type 2 DM based on HbA1C level indicates that there is an autooxidation of glucose which results in persistent production of thiols and carbonyl leading to protein damage modification due to amino acid residues fragmentation of amino acid stress and raised proteolytic susceptibility Protein thiols and carbonyl are the results of oxidation of amino acid which is nonspecific or by specific amino acid oxidationA case control comparative study was done with type 2 DM and normal control at BMCH RC Chitradurga The maximum number were of the age group of 4145 ie 32 The mean FBS levels among cases and controls 19750 mgdl and 9348 mgdl respectively There was significant difference between levels of protein content 456019 protein carbonyl 120008 and protein thiol levels 142010 among diabetics in comparison to protein content 540031 protein carbonyl 090006 and protein thiols 212012 in controls It was found that there was significant increase of protein carbonyl decrease protein content and decrease in protein thiols in diabetic patients Keywords Diabetes mellitus Oxidative stress Reactive oxygen species Protein content Protein carbonyl Protein thiols
Authors and Affiliations
Asfia Afreen, Dinesh Javarappa
Keywords
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- EP ID EP475200
- DOI 10.18231/2394-6377.2018.0094
- Views 67
- Downloads 0
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