Evaluation of Maculopathy in Patients Using Hydroxychloroquine
Journal Title: TÜRK OFTALMOLOJİ DERGİSİ - Year 2019, Vol 49, Issue 3
Abstract
Objectives: To determine length of hydroxychloroquine use and cumulative dose and evaluate the ocular effects by 10-2 central visual field test, microperimetry (MP), color fundus photography, optical coherence tomography (OCT), and fundus autofluorescence (FAF) in hydroxychloroquine users. Materials and Methods: Patients who used hydroxychloroquine continuously for at least 2 years for various connective tissue diseases were included in the study. A total of 300 eyes of 150 patients aged 19-78 years who were followed due to risk of developing hydroxychloroquine maculopathy in the İstanbul University İstanbul Faculty of Medicine Ophthalmology Department between the years 1995-2017 were evaluated. Best corrected visual acuity (BCVA), biomicroscopic, and fundoscopic examination were performed at all visits. MP, FAF, OCT, fundus photography, and central 10-2 visual field examinations were performed 3 times at 6-month intervals. Results: The mean age of patients was 48.9±10.8 years; 141 (94%) patients were female and 9 (6%) were male. The mean duration of hydroxychloroquine use was 10.5±6.4 (2-30) years. Fifty-six patients had been using the drug for 5 years or less. The mean cumulative drug dose was 754.7±447.2 (146-1825) g. Mean BCVA was 0.02±0.08 LogMAR at all follow-up visits (p=0.999). Mean MP values at the first, second, and third examinations were 14.07±3.24 dB, 14.18±3.35 dB, and 14.54±2.79 dB, respectively (p>0.05). Mean central macular thickness was 221.9±19.8 μm at initial examination, 221.8±19.9 μm at the second visit, and 221.8±19.8 μm at the final visit (p=0.113). There was a weak negative correlation between age and MP values at all three visits (visit 1: p=0.003, r=-0.170; visit 2: p=0.001, r=-0.185, visit 3: p=0.011, r=-0.146). There was statistically significant relationship between MP values and hydroxychloroquine length of use and cumulative dose (p=0.027 and p=0.049, respectively). Duration of use was not associated with changes in 10/2 visual field (p=0.124). There were significant relationships between alterations in FAF and hydroxychloroquine length of use and cumulative dose (p=0.027 and p=0.049, respectively). Conclusion: FAF alterations were significantly associated with duration of hydroxychloroquine use and cumulative dose. As objective methods are more reliable, examinations such as FAF can be recommended as auxiliary methods in the follow-up and early detection of toxic maculopathy.
Authors and Affiliations
Adem Uğurlu, Maisa Aslanova, Zafer Cebeci, Nur Kır Mercül
Sodyum Selenitle Oluşturulmuş Deneysel Katarakt Modelinde Sesamolün Koruyucu Etkisi
Amaç: Deneysel katarakt modelinde sesamolün potansiyel koruyucu etkilerini araştırmaktır. Gereç ve Yöntem: Yirmi bir adet Spraque Dawley cinsi sıçan yavrusu rastgele bir şekilde her birinde 7 sıçan bulunan üç gruba ayrıl...
İnternal Limitan Membran Soyulması ile Birlikte Vitreoretinal Cerrahi Uygulanan İdiyopatik Maküla Deliği Olgularında Ganglion Hücre-İç Pleksiform Tabaka Kalınlığının Değerlendirilmesi
Amaç: İdiyopatik maküla deliği (MD) olgularında vitrektomi ile birlikte internal limitan membran (İLM) soyulmasının ganglion hücre-iç pleksiform tabaka (GHİPT) kalınlığına etkisinin spektral domain optik koherens tomogra...
Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty in Eyes with Perforated Infectious Corneal Ulcer
Objectives: To evaluate the outcomes of penetrating keratoplasty performed for therapeutic and tectonic purposes in eyes with perforated infectious corneal ulcer. Materials and Methods: This retrospective study included...
Graft-Versus-Host Hastalıklı Bir Hastada Kristal Keratopatinin Alışılmışın Dışındaki Seyri
Bu yazıda Graft-versus-Host hastalığı olan bir hastada mantar keratitine bağlı gelişen enfeksiyöz kristalin keratopati olgusunu sunmayı amaçlamaktayız. Elli bir yaşındaki erkek hasta her iki gözünde gelişen kuru göz ve t...
Pneumatic Displacement of a Dense Sub-inner Limiting Membrane Pre-macular Hemorrhage in Dengue Maculopathy: A Novel Treatment Approach
Sub-inner limiting membrane (ILM) hemorrhage is a rare presenting feature of dengue maculopathy. A 24-year-old man in active military service who was recently treated for dengue hemorrhagic fever presented with sub-ILM b...