Evaluation of Nanosuspensions for Absorption Enhancement of Poorly Soluble Drugs: In Vitro Transport Studies Across Intestinal Epithelial Monolayers
Journal Title: The AAPS Journal - Year 2008, Vol 10, Issue 3
Abstract
Budesonide and spironolactone nanosuspensions type DissoCubes® were manufactured by high-pressure piston gap homogenization (Emulsiflex®-C50, Avestin Inc, Ottawa, Canada). Budesonide nanosuspension consisted of 10% budesonide, 5% Octosol 449 (potassium oleate) and 85% water. Spironolactone nanosuspension type DissoCubes® consisted of 10% spironolactone, 0.5% Octowet70 PG (sodium dioctyl sulfosuccinate) and 89.5% water. The mean particle diameters in the nanosuspensions were 581 nm for budesonide and 515 nm for spironolactone, respectively (PCS, Zetasizer 3000 HS Malvern Instruments Ltd, UK).
Authors and Affiliations
T. Lenhardt, G. Vergnault, P. Grenier, D. Scherer, P. Langguth
Keywords
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- EP ID EP681626
- DOI 10.1208/s12248-008-9050-7
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