Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent pharmaceutical topical gel formulation
Journal Title: The AAPS Journal - Year 2001, Vol 3, Issue 3
Abstract
The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.
Authors and Affiliations
Mark S. Kemper, Edgar J. Magnuson, Stephen R. Lowry, William J. McCarthy, Napasinee Aksornkoae, D. Christopher Watts, James R. Johnson, Atul J. Shukla
Keywords
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- EP ID EP682067
- DOI 10.1208/ps030323
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