Evaluation of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Rheumatoid Arthritis
Journal Title: Dicle Tıp Dergisi - Year 2016, Vol 43, Issue 2
Abstract
Objective: The purpose of this study is to investigate the relationship of disease activity with Neutrophil-Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) and red blood cell distribution width (RDW). Methods: Seventy seven RA patients and 97 healthy subjects were examined retrospectively. People with chronic and systemic diseases were excluded from control group of the study. The disease activity scores (DAS 28) of patient group, hematologic parameters and inflammation parameters of both groups were analyzed statistically using independent t-test and spearman correlation test. Results: Age and gender was not found different between groups. CRP and ESR levels were significantly higher in RA group (p<0.001). Hemoglobin and platelet count were lower (p<0.001 and p=0.022), while RDW, NLR, PLR and MPV levels were significantly higher in RA group (p<0.001, p<0.001. p<0.001, p<0.001, respectively). In patient group, ESR (p<0.001), lymphocytes (%) (p= 0.042), absolute neutrophil (p=0.047), and platelets (p= 0.019) were positively, whereas lymphocytes were negatively affected by improvement disease activity (DAS 28) scores. PLR levels significantly negatively correlated with MPV levels (r= -0.386) but showed a significant positive correlation with RDW (r= 0.354) and NLR levels (r= 0.618). Conclusion: NLR and PLR are important and promising factors for disease activity estimation of rheumatoid arthritis and may be used in clinical practice. In our opinion, larger studies consisting larger group will help determination of disease activity of RA by more specific indices using these parameters. Key words: Neutrophil-lymphocyte ratio (NLR), Platelet Lymphocyte Ratio (PLR), Red blood cell distribution width (RDW), Rheumatoid arthritis (RA), İnflammation
Authors and Affiliations
Elif Kilic, Aylin Rezvani , Aybala Toprak, Hayriye Erman, Siddika Ayhan, Emine Poyraz, Nihal Ozaras
Keywords
Related Articles
- EP ID EP164588
- DOI 10.5798/diclemedj.0921.2016.02.0674
- Views 135
- Downloads 0
Emetropik gözlerde pentacam ile ön segment parametrelerinin yaş gruplarına göre karşılaştırılması
Amaç: Emetrop olgularda Pentacam HR cihazı ile alınan ön segment parametrelerini yaş gruplarına göre karşılaştırılması amaçlandı. Yöntemler: Çalışmaya katılan 145 emetrop olgunun 290 gözüne ait Pentacam parametreleri de...
Current pharmacological agents for the treatment of premature ejaculation
This study was aimed to review and assess the update studies regarding medical treatment for premature ejaculation (PE). It is the most common sexual problem affecting men. It can affect men at all ages and has a serious...
The calibration of the percutaneous nephrolithotomy instruments used in pediatric patients with renal stones
The heart with single ventricle detected by exhumation and forensic autopsy: A case report
Single ventricle heart is a rare cardiac abnormality identified by just a single ventricle involving various functional and physiological defects. This abnormality may cause sudden cardiac death. In this case, we report...
Role of carotid body for neuronal protection in experimental subarachnoid haemorrhage
Objective: Carotid bodies are known as main arterial chemoregulatory units. Despite well known that carotid bodies have an important role in cerebral circulation and blood pH regulation, their roles has not been inves...