Evaluation of Nootropic activity of Two Marketed Drugs of Bacopa monnieri In Scopolamine Induced Amnesic Models
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 2
Abstract
Evaluation of Nootropic activity of Two Marketed Drugs of Bacopa Monnieri In Scopolamine Induced Amnesic Models. The Learning and memory parameters were evaluated by using Morris water maze and Passive avoidance model in Swiss albino mice. The two marketed products of Bacapa monnieri was administered at a dose of 100 mg/kg body weight orally for 14 days to the respective groups. Piracetam (400mg/kg,i.p.) was used as a standard nootropic agent. It was observed that two products of B.monniere at the above-mentioned dose after 14 days of administration in the respective groups significantly reversed scopolamine (40mg/kg i.p.) induced amnesia, as evidence by a decrease in the acquisition and retension phases were in the and step down latency in the passive avoidance task. In this study brand 2 shown significant response when compare to brand-1, may be due to reduction in the brain ChE activity in mice may prove to be a useful memory restorative agent in the treatment of dementia seen in Alzheimer’s disease.
Authors and Affiliations
D. V Kishore, R Sridhar Babu, Arshiya Begum, Amatun Noor, Saba Farheen, Syeda Maimoona Kauser, Ahmed Abdul Majid Yaser
Keywords
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