IN-VIVO ANTI-INFLAMMATORYACTIVITY OF METHANOLIC EXTRACT OF CISSUS REPANDA
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The present investigation deals with the in-vivo acute toxicity studies and in-vivo anti-inflammatory activity by Carrageenan induced rat paw edema model of methanolic extract in the stems of Cissus Repanda. TheLiterature review reveals the presence of steroids, flavonoids, triterpenoids, and glycosides in Cissus Repanda. Some plants belonging to Cissus genus have been reported to possess anti-inflammatory activity hence methanolic extract of stems of C. Repanda were screened for anti-inflammatory activity. Carrageenan induced significant inflammation when compared with the animals treated with the extracts. Standard drug, indomethacin at 10 mg/kg inhibited the inflammation significantly at all-time intervals. C.Repanda exhibited significant antiinflammatory activity in dose dependant manner. C.Repanda inhibited the carrageenan induced inflammation significantly at doses of 500 and 1000 mg/kg at 2, 3, 4 and 5 hours.
Authors and Affiliations
Vijay Kumar S, Satyanarayana T, Anjana Mathew, S. Chandrasekhar, Rajendra G
Keywords
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