Formulation and evaluation of Lornoxicam transferosomes as carriers for effective transdermal drug delivery
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 3, Issue 6
Abstract
The aim of this research activity is to formulate Soyalecithin based Transfersomal Nanoparticles for percutaneous administration of Lornoxicam for better management against pain, especially inflammatory diseases of joints. In the research work the I.R peaks obtained for the physical mixture of Lornoxicam was mostly identical with the pure sample of Lornoxicam indicating their compatibility. Lornoxicam Transfersomes were formulated by employing thin film hydration followed by High speed homogenization technique. Drug entrapment efficiency of optimized formulation “F8” was found to be 50.66%. In-vitro diffusion studies of all the formulations revealed that the Lornoxicam transfersomes followed first order kinetics, ascertaining Higuchi mechanism. Based on the satisfied release studies of all the formulations, F8 was confined to be the optimized formulation with the release of -52.35±0.214% at the end of 24H.The particle size of the formulation F8 was found to be 106.7nm indicating that the formulation was well within the Nanosomal range. The zeta potential value of the formulation F8 was found to be −2.7mv indicating negative surface charge leading to stability. Based on the results, the formulation F8 was considered as the better formulation (% Entrapment efficiency- 50.66%, Zeta Potential- −2.7mv, % Drug diffusion - 52.35±0.214%) for the effective management of against pain, especially inflammatory diseases of joints.
Authors and Affiliations
Karanki Pavani, M. Kishore Babu
Keywords
Related Articles
- EP ID EP33357
- DOI -
- Views 302
- Downloads 0
AN OVERVIEW ABOUT PHARMACY EDUCATION IN INDIA
If the current trend toward automation continues, there will be severe cuts in the employment of pharmacists in pharmaceutical industries in India. To survive in society as a professional, the pharmacist will have to f...
SUSTAINED RELEASE DRUG DELIVERY SYSTEM
The oral route is the most popular route used for administration of drugs, which is due in part to the ease of administration and to the fact that gastrointestinal physiology offers more flexibility in dosage form desi...
Formulation and evaluation of transdermal patches of Irbesartan
The purpose of the research was to develop matrix type transdermal therapeutic system containing irbesartan with different ratios of hydrophilic and hydrophobic polymeric concentration by the solvent evaporation techni...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF GEMIFLOXACIN AND AMBROXOL IN SOLID DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
The present investigation describes about a simple rapid, accurate, precise and reproducible validated reverse phase HPLC method was developed for the determination of Ambroxol and Gemifloxacin in tablet dosage forms....
Comparative in-vitro dissolution study of five brands of Diclofenac sodium delayed release tablets in QbD environment
Diclofenac sodium tablets are available as delayed release tablets in the market. Delayed release tablets are typically produced by coating the tablet with enteric coating polymers. These polymers provide the resistanc...