Formulation and evaluation of Lornoxicam transferosomes as carriers for effective transdermal drug delivery
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 3, Issue 6
Abstract
The aim of this research activity is to formulate Soyalecithin based Transfersomal Nanoparticles for percutaneous administration of Lornoxicam for better management against pain, especially inflammatory diseases of joints. In the research work the I.R peaks obtained for the physical mixture of Lornoxicam was mostly identical with the pure sample of Lornoxicam indicating their compatibility. Lornoxicam Transfersomes were formulated by employing thin film hydration followed by High speed homogenization technique. Drug entrapment efficiency of optimized formulation “F8” was found to be 50.66%. In-vitro diffusion studies of all the formulations revealed that the Lornoxicam transfersomes followed first order kinetics, ascertaining Higuchi mechanism. Based on the satisfied release studies of all the formulations, F8 was confined to be the optimized formulation with the release of -52.35±0.214% at the end of 24H.The particle size of the formulation F8 was found to be 106.7nm indicating that the formulation was well within the Nanosomal range. The zeta potential value of the formulation F8 was found to be −2.7mv indicating negative surface charge leading to stability. Based on the results, the formulation F8 was considered as the better formulation (% Entrapment efficiency- 50.66%, Zeta Potential- −2.7mv, % Drug diffusion - 52.35±0.214%) for the effective management of against pain, especially inflammatory diseases of joints.
Authors and Affiliations
Karanki Pavani, M. Kishore Babu
Keywords
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