The prescription of L-Carnitine in the treatment of Non-alcoholic fatty liver disease; A randomized and controlled clinical trial
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 4
Abstract
Non-alcoholic fatty liver disease (NAFLD) consists of a range of consumption. The disease comprises clinical, Para clinical and pathological conditions from simple steatosis in non-alcoholic steatohepatitis (NASH) to fibrosis, cirrhosis and finally to hepatocellular carcinoma. The purpose of this study is to evaluate the grade of fatty liver and LFT in NAFLD patients. 80 patients referred to gastrointestinal clinic of Emam Reza hospital with sonography diagnosed NAFLD were evaluated in two groups in a randomized clinical trial. The effects of BID dose of L-Carnitine (500 mg) on liver enzymes and echogenicity changes in case group was documented and compared with control group. The mean age of the patients was 40.7±8 in the age range of 25 to 62 years old. 66 (82.5%) of the patients were male and 14 (17.5%) of them were female. Fatty liver changes were not significantly different in the two groups (P=0.23). After a 24-week interval, the ALT was the only enzyme with significant changes (P=0.01). The difference in fatty liver sonographic grading was also significant in the two groups (P=0.0001). Considering the significant changes both in enzymatic levels and sonographic grading between the two groups of patients with NAFLD, proper therapeutic protocols can be adopted beside diet and weight loss to control the disease trend.
Authors and Affiliations
Mohamad Hosein Somi, Ebrahim Fatahi, Jafar Panahi, MohamadReza Havasian, Arezo Judaki
Keywords
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