EVALUATION OF ORAL GLUCOSE TOLERANCE EFFICACY OF VARIOUS SOLVENT EXTRACTS OF MYRISTICA FRAGRANS SEEDS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 11
Abstract
Background. Myristica fragrans Houtt. (Myristicaceae) is a tropical evergreen tree, whose seeds are well known and used in cuisine of a number of countries as a spice. As part of our ongoing screening studies to examine oral glucose tolerance efficacy of various plant and plant part extracts, it was of interest to evaluate the oral glucose tolerance efficacy of various solvent extracts of seeds of the plant. Methods. Oral glucose tolerance test (OGTT) was done to evaluate glucose tolerance. Results. In oral glucose tolerance tests, methanol extract of seeds lowered blood glucose levels in glucose-loaded mice by 58.8 and 61.4%, respectively, at doses of 200 and 400 mg per kg body weight. Petroleum ether fraction of seeds at the same two doses reduced blood glucose levels by 62.0 and 63.6%. n-Hexane fraction at the above two doses reduced blood glucose by 58.5 and 60.7%. Finally, chloroform fraction at the same two doses reduced blood glucose vlevels by 64.0 and 65.1%. By comparison, a standard antihyperglycemic drug, glibenclamide, reduced blood glucose levels by 63.3% at a dose of 10 mg per kg. Conclusion. Various solvent extracts of Myristica fragrans seeds may prove useful as blood glucose lowering agents in diabetic patients and also in discovery of novel blood glucose lowering drugs.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP627607
- DOI -
- Views 107
- Downloads 0
DETERMINATION OF THE INSILICO ANTIBACTERIAL ACTIVITY OF AMLODIPINE
The dihydropyridine amlodipine was proven to be very effective bactericidal. Here we attempted to propose a possible mechanism of action of amlodipine as antibacterial by insilico docking at the catalytic domain (CA) of...
HYPERGLYCEMIC EFFECT OF ARTOCARPUS HETEROPHYLLUS SEED METHANOL EXTRACT
Background: The leaves of Artocarpus heterophyllus have previously been shown to give hypoglycemic activity in alloxan diabetic rats. Since seeds of the plant are consumed in Bangladesh, it was of interest to evaluate th...
GENETIC POLYMORPHISM AND SERUM LEVEL OF VASCULAR ENDOTHELIAL GROWTH FACTOR ASSOCIATED WITH FIRST TRIMESTER PREGNANCY OUTCOME IN ICSI PROGRAM
VEGF plays an important role in normal physiological processes that require increased vascularization to bring oxygen and nutrients to tissues, including embryonic development. This study determine the relationship betwe...
EVALUATION OF ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF THE CRUDE EXTRACT OF NIGELLA SATIVA SEEDS ON THE BACTERIAL ISOLATES OF WOUND
Background: Nigella sativa (Black cumin, Habbatussawda) is a medicinal herb used in the treatment of many infectious and non infectious ailments. Objective: To investigate the effect of the antibacterial activities of th...
CONCEPT OF POST-STROKE DEPRESSION IN AYURVEDA: A SCIENTIFIC REVIEW
A complex picture is emerging in which the sequence of causality seems to spiral on itself as the medical science is learning more about the interaction between depression and cerebrovascular disease (CVD). Progressive b...