Evaluation of Osteopontin in Combination with Bone Turnover Markers for the Assessment of Osteoporosis in Postmenopausal Women
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 6
Abstract
Aims: Osteoporosis, a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, has an important impact on the lives of postmenopausal women, owing to the increased risk of fractures. Although bone mineral density (BMD) is the standard criteria used for the diagnosis of osteoporosis, but BMD provides a slow and static picture of skeleton whereas, the biochemical markers of bone turnover (BTM) can provide dynamic status of bone remodeling and rapid measurement of skeletal metabolism. Osteopontin (OPN), a glycoprotein has been implicated in bone remodeling by activating the resorption process. Combination of osteopontin with classical bone turnover markers can enhance the confidence of detecting osteoporosis and predicting fracture risk. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pathology, Quaid-e-Azam Medical College, Pakistan from 1st July 2015 to 15th September 2015. Methodology: We included 120 females (60 postmenopausal, age >45 years and 60 from childbearing age 25-45 years) and excluded all conditions affecting bone metabolism. Enzyme-linked immunosorbent assay technique was used to measure levels of bone markers in serum. Results: Bone markers were significantly higher in postmenopausal group of patients. Osteopontin was found to be positively correlated with osteocalcin (r=0.82), bALP (r=0.76), CTX (r=0.62) and DPD (r=0.49) and it was negatively correlated with BMD lumbar spine (r= -0.71) indicating a significant correlation (p<0.0001). The osteopontin and osteocalcin combination showed highest sensitivity (94%) and specificity (88%), closely followed by that of osteopontin and bone alkaline phosphatase combination. Conclusion: High levels of osteopontin in postmenopausal women are associated with low BMD, raised levels of bone turnover markers and fractures. When used in combination with other bone turnover markers, it can provide an accurate assessment of osteoporosis and fracture risk.
Authors and Affiliations
Sara Reza, Asma Shaukat, Maria Mahmud, Tariq M. Arain, Umama Reza, Faryal Waheed
Keywords
Related Articles
- EP ID EP340345
- DOI 10.9734/BJMMR/2016/24738
- Views 67
- Downloads 0
Use of Propolis in Cancer Research
Interest to develop new anticancer drugs and to design combination treatments with little or no secondary effects provides new scope for traditional phytochemicals in chemoprevention and therapy. Propolis is a known sour...
Musculoskeletal Disorders in Male and Female Patients and Related Factors
Aim: The aim of the study is to find differences and factors associated to musculoskeletal disorders in male and female patients in primary health care units in Egypt. Subjects and Methods: This is an exploratory cross-s...
Long Term Clinical Course of Hemodynamic Stable Pulmonary Embolism
This study aimed to review the mortality rate of pulmonary embolism (PTE) during one year follow up, incidence of hemorrhagic complications and other causes of death. This prospective cohort study was conducted on 245 pa...
Burden and Pattern of Cancer in the Sudan, 2000-2006
Aims: The aim of this study is to determine the number of newly diagnosed cancer cases and their distribution in two cancer-care providing facilities in Sudan. Study Design: This is a retrospective descriptive study. M...
Radiographic Prevalence and Clinical Significance/ Etiology of Elongated Styloid Process in Females
Aims: The aim of the present study was to investigate the radiographic prevalence of elongation and calcification in styloid complex and its clinical significance and etiology in female patients attending Taibah Universi...