Evaluation of Osteopontin in Combination with Bone Turnover Markers for the Assessment of Osteoporosis in Postmenopausal Women
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 14, Issue 6
Abstract
Aims: Osteoporosis, a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, has an important impact on the lives of postmenopausal women, owing to the increased risk of fractures. Although bone mineral density (BMD) is the standard criteria used for the diagnosis of osteoporosis, but BMD provides a slow and static picture of skeleton whereas, the biochemical markers of bone turnover (BTM) can provide dynamic status of bone remodeling and rapid measurement of skeletal metabolism. Osteopontin (OPN), a glycoprotein has been implicated in bone remodeling by activating the resorption process. Combination of osteopontin with classical bone turnover markers can enhance the confidence of detecting osteoporosis and predicting fracture risk. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pathology, Quaid-e-Azam Medical College, Pakistan from 1st July 2015 to 15th September 2015. Methodology: We included 120 females (60 postmenopausal, age >45 years and 60 from childbearing age 25-45 years) and excluded all conditions affecting bone metabolism. Enzyme-linked immunosorbent assay technique was used to measure levels of bone markers in serum. Results: Bone markers were significantly higher in postmenopausal group of patients. Osteopontin was found to be positively correlated with osteocalcin (r=0.82), bALP (r=0.76), CTX (r=0.62) and DPD (r=0.49) and it was negatively correlated with BMD lumbar spine (r= -0.71) indicating a significant correlation (p<0.0001). The osteopontin and osteocalcin combination showed highest sensitivity (94%) and specificity (88%), closely followed by that of osteopontin and bone alkaline phosphatase combination. Conclusion: High levels of osteopontin in postmenopausal women are associated with low BMD, raised levels of bone turnover markers and fractures. When used in combination with other bone turnover markers, it can provide an accurate assessment of osteoporosis and fracture risk.
Authors and Affiliations
Sara Reza, Asma Shaukat, Maria Mahmud, Tariq M. Arain, Umama Reza, Faryal Waheed
Keywords
Related Articles
- EP ID EP340345
- DOI 10.9734/BJMMR/2016/24738
- Views 60
- Downloads 0
Role of Different Ovulation Induction Protocols in Follicular Growth, Estradiol and Pregnancy Rates for Women with Unexplained Infertility and Polycystic Ovary Syndrome Undergoing Intrauterine Insemination
Introduction: The study aimed to study the effects of ovulation induction programs on the number of pre-ovulatory dominant follicles and endometrial thickness, their effects on pre-ovulatory estradiol 2 levels, and to de...
The Association between Knee Osteoarthritis and Changes in the Achilles Tendon: A Cross-sectional Study
Aim: To explore the association between knee osteoarthritis (OA) and morphological changes in the Achilles tendon. Study Design: Pilot cross-sectional study. Place and Duration of the Study: Rheumatology Unit, Barzilai M...
Thrombolytic, Cytotoxic and Antidiabetic Effects of Paederia foetida L. Leaf Extract
Aims: This research investigated the thrombolytic, cytotoxic and antidiabetic effects of Paederia foetida leaf methanol extract. Place and Duration of Study: Department of Genetic Engineering and Biotechnology and Depar...
Medical Students’ Knowledge and Attitudes towards Self-Medication in Al-Iraqia University, Baghdad, Iraq
Introduction: Self-medication is a serious issue worldwide and its irrational use becomes a major cause of global concern. Aims: The present study aimed to determine the knowledge of and attitude of students towards sel...
Antibiotic Use, Cost, and Consumption in Tertiary Hospitals in Lebanon: A Comparative Study Before and After an Implementation of Antibiotic-Restriction Program (ARP)
Aims: To compare the antibiotic use, cost, and consumption before and after an implementation of an antibiotic-restriction program (ARP) in governmental hospitals setting in Lebanon. Study Design: A retrospective cohort...