Use of Propolis in Cancer Research
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 8, Issue 2
Abstract
Interest to develop new anticancer drugs and to design combination treatments with little or no secondary effects provides new scope for traditional phytochemicals in chemoprevention and therapy. Propolis is a known source of polyphenols, and flavonoids found in them have been widely studied as biochemical markers for botanical origin and in explaining their antioxidant capacity as a key factor in chemoprevention. Antimicrobial, anti-inflammatory and anticancer biological activities of propolis are known. Studies of cancer cells to measure the anticancer effect of propolis are designed with one carefully chosen component, and with extracts applied to cells in culture media. The antitumor effect of propolis and caffeic acid phenethyl ester (CAPE), bioactive compound of propolis extract, is seen to be associated with its ability to initiate apoptosis of cancer cells. Chrysin is a flavonoid of interest to identify signaling molecules related to cancer. As cancer cells develop multidrug resistance (MDR) during chemotherapy, this opens a new avenue of research on cellular mechanisms of propolis components in combined treatments designed to overcome MDR.
Authors and Affiliations
P. Vit, F. Huq, O. M. Barth, M. Campo, E. M. Pérez-Pérez, F. A. Tomás-Barberán, E. L. Santos
Keywords
Related Articles
- EP ID EP347617
- DOI 10.9734/BJMMR/2015/16216
- Views 66
- Downloads 0
Screening for Glucokinase (GCK) Gene Mutation in Gestational Diabetes Women in Western Region of Saudi Arabia
Aim: The study involved screening of three exons of glucokinase gene (7, 8 and 9) to detect mutations at posi¬tions 682A>G, p.T228A, 895G>C, p.G299R and 1148C>A, p.S383X, respectively in Saudi pregnant women with or with...
Association between Body Mass Index (BMI) and Glycemic Control in Patients with Type 2 Diabetes Mellitus Admitted in a Rural Teaching Hospital in the State of Kerala, India – A Pilot Study
Aim: To determine body mass index (BMI) of all hospitalized type 2 diabetic patients and its association with HbA1C value Study Design: Pilot cross-sectional study. Place and Duration of Study: Department of Medicine, M...
The Relationship between Brain Dominance and Academic Performance: A Cross-sectional Study
Aims: To study the relationship between brain dominance and academic performance among undergraduates. Study Design: Cross-sectional study. Place and Duration of Study: Melaka Manipal Medical College (MMMC), Melaka campu...
Activity of Autonomic Nervous System, Energy Expenditure and Assessment of Oxidative Stress in Menopause-women Using Hormone Replacement Therapy
Aims: Menopause is a period of significant physiological change that may be associated with increased body weight and obesity-related diseases. Many studies have been carried out to determine influences of estrogen deple...
Effect of Age and Gender Variation in Normal Pituitary Gland Height Using Magnetic Resonance Imaging
Aims: The aim of this study was to analyze the age and sex related changes in pituitary gland height in a selected population from Sudan, and also to compare findings with those of other authors. Study Design: This prosp...