Evaluation of Phosphorylated Proteins Involved in the Epidermal Growth Factor Receptor (EGFR) Signaling Pathway to Predict the Response of Patients with Breast Cancer to Neoadjuvant Chemotherapy Regimens with Weekly Paclitaxel: Preliminary Analysis
Journal Title: Journal of Oncology and Cancer Research - Year 2017, Vol 1, Issue 1
Abstract
This preliminary analysis aimed at evaluating the capacity of epidermal growth factor receptor (EGFR) signaling pathway phosphorylated proteins as predictors of the pathologic response of breast cancer patients treated weekly with neoadjuvant paclitaxel. Pathologic response was graded based on the Miller-Payne system. The Luminex method was used to measure the phosphorylation state of 22 proteins involved in the EGFR signaling pathway in the tumor samples of 40 patients. Good pathologic response (≥ 90% tumor reduction) was observed in 10 patients. Comparing patients grouped as good and poor pathologic response to treatment, we found no statistically significant differences among the proteins analyzed. On the other hand, the percentage of tumor reduction after paclitaxel was inversely correlated to the expression of phosphorylated HER2 protein (Pearson correlation: r=-0.353; p=0.027). The current analysis demonstrated that the overexpression of phosphorylated HER2 (pY1023) in primary breast cancer tissue is predictive of lower response to weekly paclitaxel therapy. However, due to the high heterogeneity of breast cancer, the verification and predictive value of the overexpression of phosphorylated proteins requires further studies, with a larger number of patients, which may prompt more individualized treatment for cancer patients in the future.
Authors and Affiliations
Nilciza MCT Calux, Márcia DA SILVA-MAZON, Debora C Moreira, Tatiana CS Bonetti, Afonso CP Nazário, Ismael DCG Silva, Gil Facina
Keywords
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- EP ID EP249325
- DOI 10.28967/jocr.2017.01.17006
- Views 108
- Downloads 0
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