Evaluation of plant extracts in the management of caustic burns: Irritation / Acute dermal corrosion. Bogotá-2018
Journal Title: Revista Cuarzo - Year 2018, Vol 24, Issue 1
Abstract
Introduction: Considering that caustic burns represent a low percentage of burns, given the com-plications they could associate, they are a public health problem that requires new therapeutic options such as the use of plant-derived products, including Calendula offinalis, Aloe vera and Cannabis sativa, whose use is conditioned, initially to tests such as the evaluation of its acute irri-tative / corrosive effect on skin. Materials and methods: Randomized.Experimental study in animals, the plant material was obtained from the Jorge Piñeros Corpas Medicinal Garden; the oils and extracts of the plants were obtained by classical methods of phytochemical extraction; the base of excipients was supplied by the LABFARVE Laboratory. Eight-wistar rats male were used under controlled conditions an 18Revista Cuarzo - Fundación Universitaria Juan N. CorpasVol. 24 No. 1parameters of ethics and animal welfare. The test for irritation / acute skin corrosion was carried out under the OECD 404 standard, after anesthesia of the animals and following the end point criteria of pain. Results: Two essential oils and three extracts were obtained from Calendula officinalis; Aloe vera gel and an extract of Cannabis sa-tiva. None of the extracts generated eschar, erythema or edema in the animals, being negative the skin irritation / acute corrosion test. Discussion: The results obtained from this basic research in translational medicine, provide evidence that complements the infor-mation reported in the literature about traditional use and in vitro and in vivo studies of these plants for the management of various diseases. The absence of irritant or corrosive effect on skin is consistent with the knowledge with the type of chemical active com-pounds (secondary metabolites) that have been identified with anti-inflammatory, antioxidant, antimicrobial and cicatrizant activity. The results assure their chemical safety when contemplating them to investigate their potential therapeutic use in skin lesions, caustic burns, guaranteeing their safety
Authors and Affiliations
Barrera Céspedes, M. , Pombo Ospina, L. , Mancipe Vargas, J. , Duarte Hernández, A. , Hernández Montaño, J. , Rodríguez Aguirre, O. , Santander González, S. , Mejía Piñeros, A. , Núñez Jején, G. , Lagos Madero, M. , Guerreo Fajardo, L. , Londoño Valero, L. , González Alarcón, A. , & Lozada Cruz, L. del M.
Keywords
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- EP ID EP694620
- DOI https://doi.org/10.26752/cuarzo.v24.n1.351
- Views 145
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