Evaluation of Plasma Creatine Kinase Activity and Inorganic Phosphate among Sudanese Patients with Sickle Cell Disease in Khartoum and White Nile State
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
Background: CK and phosphorus are helpful biomarker for detection of early renal abnormality particularly CK which has been shown to be abetter predicator of acute renal failure. Objectives: This is a descriptive cross-sectional study. Conducted in Khartoum and White Nile state from March to June 2016.The aim of this study to assess serum creatine kinase (CK) activity and inorganic phosphate concentrations in Sudanese patients with sickle cell anemia. 80 subjects were enrolled in this study they were classified into 40 with sickle cell disease (SCD) as casegroup and 40 healthy apparently as control group. CK activity and phosphorus level was measured by using Spectrophotometry method. Results: The results showed significantly higher Ck activity in patients with SCD when compared with control group with (P = 0.021), and not significant differences in mean of serum phosphorus concentration in case when compared with control with (P = 0.547). Also show serum CK activity in patients used hydroxyurea when compare with the mean of patients not used hydroxyurea it is significantly decrease with (P= 0.006). Conclusion: The studies conclude that Sickle cell disease is a predictor for high serum CK activity and low serum concentration of inorganic phosphate.
Authors and Affiliations
Elgaili A. K. Khowgali, Husham O. Elzein2, NassrEldin M. A. Shrif 3, Amna O. M. Elzein3 *
Keywords
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- EP ID EP387283
- DOI 10.9790/3008-120101140143
- Views 49
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