Evaluation of Polyherbal formulation for Diuretic activity in albino rats
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: To investigate the diuretic potential of Polyherbal formulations prepared from the seeds of Vitis venifera, Duranta repens and Centratherum anthelminticum in Albino rats. Methods: Different concentrations of Polyherbal formulations (100, 200 and 400 mg/kg), furosemide (10 mg/kg) and vehicle were orally administered to rat (n = 6 animals per group) and their urine output was collected after 24h. The Urinary output, Osmolarity, pH, Na+, K+ and Cl- concentrations of urine were estimated. Results: The Polyherbal formulations produced significant increase in Na+, K+, Cl- excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic index and Natruretic index. All the concentrations of Polyherbal formulation showed dosedependent relationship when compared to control animals. Conclusions: These finding strongly suggests that the Polyherbal formulations have a good diuretic activity on rats in the above experimental model.
Histological and histochemical changes in placenta of diabetic pregnant females and its comparision with normal placenta
Objective: To investigate the histological and histochemical changes in placenta of diabetic pregnant females and compare them with normal placenta. Methods: The histological and histochemical features of 60 placenta, 30...
Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats
Objective: To evaluate the antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark (AEALB) in streptozotocin-nicotinamide (STZ-NIN)- induced type 2 diabetic rats...
Bioprospecting of marine Streptomycetes sp. for its antagonistic activity on MDR Pseudomonas aeruginosa and Acinetobacter baumannii isolates
Objective: To assess the antimicrobial activity of the Actinobacteria bioactive secondary metabolite and characterize the drug resistance mechanisms of Pseudomonas aeruginosa (P. aeruginosa) and Acinetobacter baumannii (...
Restorative effect of Eclipta alba in CCl4 induced hepatotoxicity in male albino rats
Objective: To elucidate the restorative effect of the aqueous leaf extract (85%) of the traditional medicinal plant Eclipta alba (E. alba) against CCl4 induced hepatotoxicity in male albino rats. Methods: Restorative act...
Thrombocytopenia in children with malaria-A study from coastal Karnataka, India
Objective: To study the occurrence and severity of thrombocytopenia in children with malaria. Methods: It was a retrospective study, done at Fr Muller Medical College Hospital Mangalore, in Karnataka, India. Data regardi...