Evaluation of Polyherbal formulation for Diuretic activity in albino rats

Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0

Abstract

Objective: To investigate the diuretic potential of Polyherbal formulations prepared from the seeds of Vitis venifera, Duranta repens and Centratherum anthelminticum in Albino rats. Methods: Different concentrations of Polyherbal formulations (100, 200 and 400 mg/kg), furosemide (10 mg/kg) and vehicle were orally administered to rat (n = 6 animals per group) and their urine output was collected after 24h. The Urinary output, Osmolarity, pH, Na+, K+ and Cl- concentrations of urine were estimated. Results: The Polyherbal formulations produced significant increase in Na+, K+, Cl- excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic index and Natruretic index. All the concentrations of Polyherbal formulation showed dosedependent relationship when compared to control animals. Conclusions: These finding strongly suggests that the Polyherbal formulations have a good diuretic activity on rats in the above experimental model.

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  • EP ID EP233642
  • DOI 10.1016/S2222-1808(12)60200-X
  • Views 88
  • Downloads 0

How To Cite

(2012). Evaluation of Polyherbal formulation for Diuretic activity in albino rats. Asian Pacific Journal of Tropical Disease, 2(0), 442-445. https://europub.co.uk/articles/-A-233642