Evaluation of protein and lipid oxidative stress in the patients with postmenopausal osteoporosis
Journal Title: Dicle Tıp Dergisi - Year 2014, Vol 41, Issue 1
Abstract
Objective: Oxidative stress may change cellular function in multiple pathological conditions, including osteoporosis. We aimed to determine malondialdehyde (MDA) levels, advanced oxidation protein pruducts (AOPP), levels end products of protein oxidation, thiol as known antioxidant, serum paraoxonase 1 (PON1) activities as known lipid antioxidant, induced by reactive oxygen species (ROS) for evaluating oxidative stress in osteoporotic patients. Methods: 59 patients diagnosed with postmenopaual osteoporosis were included in the study and compared with 21 healthy controls. Serum AOPP, MDA, thiol levels and PON1 activity were measured according to an enzymatic spectrophotometric method. Results: The serum MDA, AOPP, and thiol levels was significantly higher in the patient group than controls (p<0.05). PON1 activity was found lower in the patients group than the control group. Conclusion: Increased ROS levels in osteoporotic patients may result in a pro-oxidation environment, which in turn could result in increased MDA, AOPP. As a result, lipid peroxidation and protein oxidation may have a role in the pathogenesis of the osteoporotic patients. Key words: Lipid peroxidation, protein oxidation, osteoporosis, oxidative stress
Authors and Affiliations
Banu Çavdaroğlu, Nurgül Köse, Gülden Başkol, Hüseyin Demir
Keywords
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- EP ID EP88234
- DOI 10.5798/diclemedj.0921.2014.01.0375
- Views 112
- Downloads 0
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