Evaluation of Recombinant Human Platelet Derived Growth Factor- BB in Healing of Chronic Diabetic Foot Ulcers
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Diabetic foot problems are common throughout the world resulting in major economic consequences. Once a wound developed in diabetics it remains open for prolonged periods. Senescent and altered resident cells and certain growth factors deficiencies are incriminated for chronicity of wound. Growth factors are biologically active polypeptides that act to alter growth, differentiation and metabolism of targets cells. The present study was conducted with the aim to compare the effects of exogenous application of PGDF (platelet derived growth factor) on ulcer healing rate. Material and Methods: All patients of age group 18-80 yrs with diabetic foot ulcer of more than 4 weeks duration were taken. Patients were randomised to one of two parallel treatment groups. In group 1, standard wound Care was given. Second group was treated with local applications of recombinant human PDGF-BB along with the required wound care. Primary study end points were complete healing of ulcers,12 weeks of duration, ulcer bed adequate for possible skin closure /skin grafting. Results: Average time taken to achieve ulcer closure/skin cover at 12 weeks duration in PDGF group (38.5 days) was found to be less than in GWC (good wound care) group (63 days). Incidence of ulcer closure/skin cover at 12 weeks in patients with age less than 60 years (66.66) and non-smokers (68.18%) was found to be more than in patients with age more than 60 yrs or smokers(21.43%). Conclusion: The incidence of ulcer closure / skin cover at 12 weeks duration in PDGF group was found to be more than in GWC group and this difference was statically significant.
Authors and Affiliations
Vishal Mandial, Money Gupta, Renuka Sharma
Keywords
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