Evaluation of salivary antioxidants – Superoxide Dismutase and Glutathione Peroxidase in OSMF patients and healthy individuals – A comparative study.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 1
Abstract
Background: Saliva is the first biological medium that is encountered during chewing. Saliva provides a natural defence against harmful substances and microorganisms. Research confirms that antioxidants are among the most important elements in saliva as they help in protecting against oral diseases like premalignant lesions, conditions and cancer. Hence, they are vital to tissue health and healing. Aims and objectives: The aim of this study is to evaluate the two salivary antioxidants i.e superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and compare their levels in saliva of clinically diagnosed OSMF cases and healthy individuals. Materials and methods: The study sample consists of 40 individuals. Group 1: 20 healthy individuals without any habit. Group 2: 20 individuals with clinically diagnosed OSMF cases. Unstimulated saliva of individuals is collected. The saliva is centrifuged and the supernatant is taken and activity of two salivary antioxidant enzymes is measured according to specific assay on the spectrophotometer. Statistical analysis: The mean values of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the saliva of healthy and OSMF patients are analysed using Student‘t’ test. Results: The mean values of the control group and OSMF for salivary superoxide dismutase (SOD) are 0.0413 and 0.0858 respectively. The mean values of the control group and OSMF for salivary glutathione peroxidase (GSH-Px) are 0.1 and 0.0024 respectively. Salivary superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels between the healthy and OSMF groups shows high a significant difference.
Authors and Affiliations
Prashant Kumar
Keywords
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