Evaluation of Salivary Cardiac Troponin-I as Potential Marker for Detection of Acute Myocardial Infarction
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 7
Abstract
Introduction: Serum cardiac troponin-I is a specific biomarker and raised significantly after Myocardial Infarction. Saliva is a non-interventional bio-fluid which contains portion of serum constituents and can be key in diagnosis of MI. Aim: To estimate and correlate the level of cardiac Troponin-I (cTnI) in un-stimulated whole saliva and serum in acute MI patients and control group. Materials and Methods: Total of 60 individuals were enrolled and equally divided in to study (group I) and control group (Group II). Informed consent form was taken from all the subjects. Saliva and blood samples were obtained from patients with ECG features suggestive of acute MI within 24 hours. Serum and saliva samples were processed further for cTnI. The results obtained were then statistically analysed. Results: The mean cTnI level in serum of group I and group II were found to be 4.27±1.79 mg/L and 0.158±0.05 mg/L respectively. The mean cTnI level in saliva of group I and group II was found to be 0.67±0.10ng/L and 0.160±0.05 ng/L respectively. On analysing serum values and saliva values, p-value was found to be significant’. Conclusion: The saliva levels of cTnI were directly associated with serum levels demonstrating a highly significant strong positive relation and confirms the diagnostic ability of saliva for detection of cTnI.
Authors and Affiliations
Vaibhav Mishra, Ranjitkumar Patil, Vikram Khanna, Anurag Tripathi, Vandana Singh, Shivani Pandey, Akhilanand Chaurasia
Keywords
Related Articles
- EP ID EP526107
- DOI 10.7860/JCDR/2018/32109.11791
- Views 73
- Downloads 0
First Outbreak of Dengue in Jorhat District of Assam
ABSTRACT Introduction: Dengue Virus (DENV) infection is an important human arboviral infection. Though it is endemic in several parts of India, there has been no reported outbreak from Jorhat district of Assam, India. Ai...
Merits of Oil Pulling Therapy in the Management of Xerostomia and Stomatopyrosis in Burning Mouth Syndrome
Introduction: Burning Mouth Syndrome (BMS) is a condition which is characterised by xerostomia, stomatopyrosis, dysgeusia and primarily affects the women of perimenopausal age. Despite the plethora of trials that have be...
Evaluation of Analgesic Activity of Standardised Aqueous Extract of Withania somnifera in Healthy Human Volunteers using Mechanical Pain Model
ABSTRACT Introduction: Drugs commonly used for pain management are associated with adverse effects. Experimental pain models in human healthy volunteers are advantageous for early evaluation of analgesics. Studies with W...
Mosaicism in 22q11.2 Microdeletion Syndrome
ABSTRACT Introduction: Microdeletion syndrome is characterized by sub-microscopic chromosomal deletion smaller than 5 Million bp (5Mb) and frequently associated with multiple congenital anomalies. Fluorescent In Situ Hyb...
Fistulotomy Around The Sphincter (FATS) Procedure: A Simple New Sphincter-Sparing Concept to Treat High Fistula-In-Ano
ABSTRACT Fistulotomy Around The Sphincter (FATS) is a novel sphincter sparing procedure for high anal fistulas. In FATS procedure, the fistula tract from internal opening to external opening is laid open except that the...