Evaluation of Salivary Cardiac Troponin-I as Potential Marker for Detection of Acute Myocardial Infarction
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 7
Abstract
Introduction: Serum cardiac troponin-I is a specific biomarker and raised significantly after Myocardial Infarction. Saliva is a non-interventional bio-fluid which contains portion of serum constituents and can be key in diagnosis of MI. Aim: To estimate and correlate the level of cardiac Troponin-I (cTnI) in un-stimulated whole saliva and serum in acute MI patients and control group. Materials and Methods: Total of 60 individuals were enrolled and equally divided in to study (group I) and control group (Group II). Informed consent form was taken from all the subjects. Saliva and blood samples were obtained from patients with ECG features suggestive of acute MI within 24 hours. Serum and saliva samples were processed further for cTnI. The results obtained were then statistically analysed. Results: The mean cTnI level in serum of group I and group II were found to be 4.27±1.79 mg/L and 0.158±0.05 mg/L respectively. The mean cTnI level in saliva of group I and group II was found to be 0.67±0.10ng/L and 0.160±0.05 ng/L respectively. On analysing serum values and saliva values, p-value was found to be significant’. Conclusion: The saliva levels of cTnI were directly associated with serum levels demonstrating a highly significant strong positive relation and confirms the diagnostic ability of saliva for detection of cTnI.
Authors and Affiliations
Vaibhav Mishra, Ranjitkumar Patil, Vikram Khanna, Anurag Tripathi, Vandana Singh, Shivani Pandey, Akhilanand Chaurasia
Keywords
Related Articles
- EP ID EP526107
- DOI 10.7860/JCDR/2018/32109.11791
- Views 59
- Downloads 0
Effects of 60° Semi-recumbent Position on Preventing Ventilator-associated Pneumonia: A Single-blind Prospective Randomised Clinical Trial
Introduction: Head-of-Bed Elevation (HOBE) is now considered as a main modifiable factor for decreasing Ventilator-Associated Pneumonia (VAP) especially in the area of intensive care nursing. Despite numerous studies on...
An Aggressive Primary Retroperitoneal Diffuse Large B-Cell Lymphoma Mimicking a Pancreatic Neoplasm, Presenting as Duodenal Stenosis
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin’s Lymphoma (NHL). Primary retroperitoneal DLBCL is uncommon and has seldom been reported. Extrinsic compression of the duodenum...
Role of Hepcidin on Response of Erythropoietin Stimulating Agents in Anaemic Advanced Chronic Kidney Disease Patients
ABSTRACT Introduction: Anaemia contributes significantly to the morbidity and mortality in Chronic Kidney Diseases (CKD). Erythropoietin Stimulating Agents (ESA) have revolutionised the management of the anaemia in CKD...
Successful Completion of Pregnancy on Maintenance Haemodialysis: Experience from a Resource-Short Model
Data pertaining to pregnancy completion on haemodialysis in Chronic Kidney Disease (CKD) patients from the developing world are scarce. We report three successfully completed pregnancies on Maintenance Haemodialysis (MHD...
Large Placenta and Small Foetus at Early Gestation Predicts Foetal Growth Restriction due to Placental Dysmorphology
ABSTRACT When placenta appears large on ultrasound, there are certain differential diagnoses to be kept in mind. We present a series of three cases in which large placenta was observed in first trimester scan. All three...