Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 4
Abstract
Objectives: Oral and dental manifestations in diabetic patients can arise due to numerous factors, including elevated salivary secretory immunoglobulin A (s-IgA) levels. Tis study aimed to evaluate s-IgA concentrations in patients with type 2 diabetes mellitus (T2DM) and to investigate the association between s-IgA levels and oral and dental manifestations of T2DM. Methods: Tis cross-sectional descriptive study was carried out between October 2011 and September 2012 in Kerman, Iran, and included 260 subjects (128 patients with T2DM and 132 healthy controls). Unstimulated salivary samples were collected from all subjects and s-IgA levels were determined using the immunoturbidimetric method. Te oral cavities and teeth of T2DM patients were evaluated for oral and dental manifestations. Results: Both diabetic and control subjects with higher concentrations of s-IgA had signifcantly higher numbers of decayed, missing or flled teeth (DMFT) and periodontal index (PDI) scores (P <0.050). s-IgA levels were signifcantly higher in subjects with oral candidiasis (P <0.050). Among diabetic patients, signifcantly higher s-IgA levels were concomitant with xerostomia and denture stomatitis (P ≤0.050). Tere were no signifcant differences between s-IgA concentrations and other oral or dental manifestations in either group. Conclusion: Individuals with a greater number of DMFT, a higher PDI score and oral candidiasis had signifcantly higher s-IgA levels. s-IgA levels were not signifcantly higher among diabetic patients in comparison to the control group. However, signifcantly higher s-IgA levels occurred with xerostomia and denture stomatitis in diabetic patients. In addition, s-IgA was signifcantly higher in patients with uncontrolled diabetes compared to those with controlled diabetes.
Authors and Affiliations
Shahla Kakoei| Departments of Oral Medicine , Oral & Dental Diseases Research, Bahareh Hosseini| Departments of Oral Medicine and Endontology Research, , Kerman University of Medical Sciences, Kerman, Iran, Ali-Akbar Haghdoost| Centers for Modeling in Health , Kerman University of Medical Sciences, Kerman, Iran, Mojgan Sanjari| Center for Endocrinology & Metabolism Diseases Research, Institute of Basic & Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran, Ahmad Gholamhosseinian| Departments of Biochemistry, Institute of Basic & Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran, Vahid F. N. Afshar| Centers for Oral & Dental Diseases Research, Institute of Basic & Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Keywords
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