Evaluation of Serum Adenosine Deaminase (ADA) Values for Detection of Pulmonary and Extra-pulmonary Tuberculosis
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: There is need of precise and faster diagnosis for pulmonary (PTB) and extra-pulmonary tuberculosis (EPTB). Accordingly, there develops a considerable interest in the development of tests based on biochemical response of body towards tuberculosis infection (i.e. estimation of serum adenosine deaminase). These tests appear to be a promising approach for the diagnosis of pulmonary as well as extra pulmonary TB. Materials & Method: Total 150 individuals recruited for this study, out of which 50 cases each of PTB and EPTB. 50 age and sex matched controls were included, out of which 15 were healthy controls and 35 were diseased controls. Serum adenosine deaminase (ADA) was estimated by using commercial ADA-MTB kit. Results: Serum ADA concentration in patients with PTB & EPTB was found to be significantly higher (p < 0.05) as compared to diseased and healthy controls. Conclusion: Our observations suggest that serum Adenosine deaminase (ADA) measurement has a good detection potential for PTB & EPTB.
Authors and Affiliations
Abhijit NinghotV, Kanchan Mohod, Satish Kumar
Keywords
Related Articles
- EP ID EP295964
- DOI 10.18231/2394-6377.2017.0025
- Views 76
- Downloads 0
Methylenetetrahydro folatereductase enzyme polymorphism associated with hyperhomocysteinemia in patients with stroke
Cerebrovascular stroke is complex heterogeneous multifactorial disorder associated with number of risk factors, including diabetes mellitus,hypertension, tobacco smoking or chewing; etc. MethylenetetrahydroFolate reducta...
Mathematical model of evaluation of Insulin Resistance using Homeostasis Model Assessment – Insulin Resistance Index in patients with Hyperthyroidism
Aim: To evaluate insulin resistance using HOMA-IR index in patients with overt and subclinical hyperthyroidism. Materials and Method: A randomized case control study on female population was conducted. For which 30 overt...
Reliability of blood gas analyzer for the measurement of electrolytes - A comparative study
Background: Electrolyte and blood gas analysis are essential for most patients who are admitted in the casualty. Routinely simultaneous arterial and venous sample would be sent to the laboratory for blood gas analysis an...
Is Placental Growth Factor an angiogenic marker in type 2 diabetes mellitus?
Introduction: Type 2 diabetes mellitus (T2DM) known by vascular complications due to abnormal angiogenesis leading to micro and macro vascular complications. PlGF a close homolog of VEGF, shares receptors with VEGF, and...
Correlation between Ischemia modified albumin with pH in acidosis and alkalosis: A possible link
Ischemia modified albumin (IMA), a recently developed marker for myocardial ischemia is measured by using albumin cobalt binding (ACB) assay. The correlation between the formation of IMA and alterations in the pH levels...