Evaluation of serum aminotransaminases and bilirubin in different treatment regimens for chronic hepatitis C virus
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 4
Abstract
Hepatitis C virus (HCV) affects more than 180 million people worldwide and it is the leading cause of chronic liver disease .The aim of this study is to detect liver enzymes and bilirubin levels before and after different anti viral therapies in Egyptian chronic hepatitis C infected patients. One hundred and fifty patients with chronic HCV infection who have anti HCV antibodies detected by ELISA were selected to undergo Real-Time polymerase chain reaction (RT-PCR) ; of them 30 blood samples were positive for HCV antibodies and negative for HCV RNA (control group I) and 120 blood samples were positive for HCV antibodies and positive for HCV RNA (diseased group II) which is subdivided into four groups according to the received treatment; interferon and ribavirin (group IIa), interferon, sofosbuvir and ribavirin (group IIb), sofosbuvir and ribavirin (group IIc) and herbal therapy (group IId). Results revealed; after treatment there was a statistical significant reduction in the mean values of ALT in group IIa, group IIb and group IIc (mean: 38.00, 45.5 and 36.00 U/L respectively; P< 0.0001) while, group IId showed a non significant decrease in ALT levels after treatment (mean: 45.0 U/L; P>0.05). AST levels showed a non significant increase after treatment in group IIa (mean: 43.7 U/L; P>0.05), a non significant decrease in group IIb and group IId (mean: 40.03 and 39.80 U/L respectively; P>0.05) and an extremely significant decrease after treatment in group IIc (mean: 28.30 U/L; P< 0.0001). Bilirubin levels showed a non significant decrease after treatment in group IIa (mean: 0.763 mg/dL; P>0.05), a non significant increase after treatment in group IIb (mean: 0.811 mg/dL; P>0.05) and an extremely significant increase in group IIc (mean: 1.05 mg/dL; P< 0.0001) while there was no significant difference in serum bilirubin levels in group IId after treatment (mean: 0.901 mg/dL; P>0.05). In conclusion, Serum ALT is a normal value after all treatment regimens included in our study; serum AST is slightly elevated in combination therapy of pegylated interferon plus ribavirin while serum bilirubin is highly elevated in case of sofosbuvir dual therapy than sofosbuvir trible therapy.
Authors and Affiliations
Fagr B. Bazeed, Elsherbeny H. Elsayed, Amani A. Abd El-Aziz2
Keywords
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- EP ID EP385017
- DOI 10.9790/3008-1104012026
- Views 111
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