Evaluation of serum lipid profile in patients with hyperthyroidism
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Thyroid dysfunctions are known to influence lipid metabolism significantly, affects lipoprotein metabolism. Hyperthyroidism is associated with lipid alterations mainly concerning total and LDL cholesterol. Materials and Method: It was a case control study. The cases and controls were screened for serum thyroid profile and complete lipid profile, the values were compared with that of normal healthy subjects. The cases were divided into two groups after studying the thyroid profile i.e. subclinical hyperthyroidism (characterized by low serum TSH with normal T4) and overt hyperthyroidism (characterized by low TSH and with elevated FT4). Results: The descriptive data was given as mean ± standard deviation. The statistical analysis was done by ANOVA and student t test. The mean difference was significant at the 0.05 level and statistically insignificant when the p value obtained was greater than 0.05. The mean serum total cholesterol & LDL levels were decreased in patients of overt hyperthyroidism as compared to controls and the difference between the levels was statistically insignificant. But the mean serum TG remain unchanged in patients and the difference was statistically insignificant. In the cases of subclinical hyperthyroidism the mean serum levels of total cholesterol, LDL & TG were decreased in patients as compared to controls & the difference was statistically insignificant. But the mean serum HDL levels was significantly decreased in patients as compared to controls. Conclusion: Thyroid function test for screening of thyroid dysfunction is great importance in all dyslipidemic patients. It is also of cardinal importance in all patients with unexpected improvement or worsening of their lipid profile. So underlying thyroid disorders should be recognized and treated in patients with dyslipidemia especially when the results are unforeseen.
Authors and Affiliations
Anju Sharma, Jaskiran Kaur, Amandeep Kaur, Neha Uppal, Mandeep Kaur
Keywords
Related Articles
- EP ID EP296050
- DOI 10.18231/2394-6377.2017.0030
- Views 80
- Downloads 0
A Study of Serum Magnesium, Calcium and Phosphorus in Hypothyroidism
Introduction: Hypothyroidism, the commonest form of hormonal dysfunction, is due to thyroid hormone deficiency or its impaired activity. Various electrolyte disturbances in association with hypothyroidism were observed i...
A study to assess the relation between severity of hypothyroidism and Lipid parameters
Background: Hypothyroidism is associated with dyslipidemia. The present study was conducted to assess the relation between hypothyroidism and lipid parameters and lipid ratios. It is also done to assess the severity of h...
Biochemical markers of renal and hepatic function in gestational diabetes mellitus
Aim: To assess the biochemical parameters of renal and hepatic function in women with GDM and compare the results with those of normal pregnant women. Materials and Methods: Cases: The study group consisted of 45women wi...
Salivary Malondialdehyde and Uric acid in Tobacco Chewers
Introduction: Tobacco in any form is responsible for the generation of free radicals which cause oxidative damage, producing lesions in the mouth like ulcers, leukoplakia, erythroplakia, sub mucus fibrosis and is respons...
Comparative study of lipid profile & lipid peroxidation in normal pregnant subjects & subjects with pre-eclampsia
Background: It is the increased responsiveness of the arterial system to pressor substances which probably causes the generalized vasoconstriction and hypertension of pre-eclampsia. In normal human pregnancy, there is de...