Evaluation of Serum Lipids, Apolipoprotein A1, Apolipoprotein BandLipoprotein(a) In Relation toBreast Cancer Risk
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
This study evaluates theassociation of serum lipids and Apolipoproteins with Breast Cancer riskin pre- and post-menopausal breast cancer women. Serum lipids and apolipoproteins were estimated in patients with Breast Cancer and Benign Breast lesion, attending Oncology Department of B.Y.L. Nair Charitable Hospital, Mumbai. The study group comprised of 147 Breast Cancer patients, 27 Benign Breast lesion and 35 normal healthy subjects serving as control group. A total of 100 Breast Cancer patients had Invasive Ductal carcinoma, 17 had Ductal carcinoma in situ and 30 presented with Infiltrating Ductal Carcinoma. Stage II or Stage III Tumour, was present in 78 % patients whereas the remaining 22 % had either Stage I or Stage IV tumour.A highly significant(p=0.0001) increase in Total Cholesterol, LDL-Cholesterol, Triglycerides, Lp(a), and Apo B/Apo A1 ratio and significant decline in HDL-Cholesterolwas presented by patients with Breast Cancer and Benign Breast lesion.The Odds ratio indicated highest risk for development of breast cancer in patients with increased levels of Total Cholesterol, LDL-Cholesterol, Triglycerides, Apo B and Apo B/Apo A1 ratio. Altered lipids and apolipoproteins cannot serve to differentiate Breast Cancer from Benign Breast Lesion.. To reduce the burden of breast cancer, a multi-sectorial approach aiming at early detection of the disease is required.
Authors and Affiliations
Vinay G Patke, Gaurav S Kansara
Keywords
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- EP ID EP363361
- DOI 10.9790/0853-1702111623
- Views 62
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