Evaluation of Serum Sarcosine, Total and Free Testosterone Levels in Patients with Prostate Disorders in Sokoto, Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 15, Issue 12
Abstract
Although radiation and surgery are generally regarded as effective for treatment of prostate cancer (PCa) in majority of men, diagnosis and prognosis remains poor in patients with progressive disease. Disease –specific metabolites represent the effective end points with considerable ability to identify men at increased risk of disease progression. In the current study, serum levels of Sarcosine, free and total testosterone (fTesto and tTesto) were assayed to evaluate the tumorigenic properties of PCa in our locality. In this study, 150 prostate cancer, 200 benign prostatic hyperplasia (BPH) Patients diagnosed and 200 volunteer matched controls were evaluated. Serum sarcosine were 64.94±0.81 nmol/dl, 118.70±1.80 nmol/dl and 134.13±2.21 nmol/dl in PCa, BPH patients and controls respectively. Serum tTesto and fTesto levels were 5.09±0.15 ng/ml, 5.12±0.11 ng/ml and 13.42±0.26 pg/ml, 5.72±0.20 ng/ml, 13.93±0.24 ng/ml and 11.73±0.47 pg/ml in PCa, BPH patients and controls respectively. Values differ significantly (p˂0.05) between PCa, BPH patients and controls in all the analytes. Attempt was also made to define the reference ranges of these analytes in various age groups of the controls. We recommend the inclusion of Serum levels of Sarcosine, tTesto and fTesto into multiplex biomarker panel for PCa and BPH detection in our localities.
Authors and Affiliations
N. K. Nnamah, P. O. Anaja, I. A. Mungadi, L. S. Bilbis, M. K. Dallatu
Keywords
Related Articles
- EP ID EP341370
- DOI 10.9734/BJMMR/2016/25285
- Views 71
- Downloads 0
Role of Doppler Navigation in Minimally Invasive Procedures under Ultrasound Guidance
Aim: To highlight the possibilities of Doppler methods to optimize navigation and control of percutaneous echo-controlled minimally invasive interventions. Study Design: 25,543 diagnostic and therapeutic minimally invasi...
Effects of a 12-week Minimum Program for Preventive Medical Purposes
Current study aimed to investigate the effects of a minimal training program combined with a nutritional intervention, an introductory health seminar and an individual health coaching on parameters for cardiovascular hea...
Primary Intracerebral Haematoma Evacuation: A Case Report
Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, leading to disability and high mortality rate. Besides blood pressure reduction and intensive medical and surgical treatment, immediate...
Adeno-Hypophyseal Consequence of Uterine Fibroid and the Effects of Ginger Extract on the Monosodium Glutamate-Induced Tumor
Background: Uterine fibroids, also referred to as uterine myomas, leiomyomas, myomatas, or simply fibroid are benign soft-tissue tumors that arise from uterine smooth muscle tissue (myometrium). They have been described...
Effect of Progressive Resistance Exercise Training on Hepatic Fat in Asian Indians with Non-Alcoholic Fatty Liver Disease
Introduction: Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity and insulin resistance and lifestyle measures form the cornerstone of therapy. Objective: To study the effect of progressive resi...