Evaluation of Serum Uric Acid in Hypertension
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 8
Abstract
Objective: We carried out a study in Sri Venkateswara medical college, Tirupati during a period of 12 months to examine the relationship between serum uric acid and hypertension. Methodology: A total of 150 patients were studied of which 75 were cases and 75 as controls. The patients were included if they satisfy the JNC VII criteria for hypertension 2. Results: The study showed that serum uric acid levels were raised in patients with hypertension in comparison to normotensives. The Mean Serum Uricacid levels between hypertensives and normotensives were 7.02± 1.12 and 4.86± 0.68 respectively. p - value = 0.001 which is shown to be significant.Our study showed significant rise in serum uric acid in hypertensives. www.jmscr.igmpublication.org Impact Factor 3.79 ISSN (e)-2347-176x B. Anil Kishore et al JMSCR Volume 2 Issue 8 August 2014 Page 2070 JMSCR Volume||2||Issue||8||Page 2069-2072||August-2014 2014 Conclusion: High serum uric acid concentrations may increase serum sodium reabsorption at nephron sites proximal to the distal tubule, and it has been proposed that metabolic perturbations such as hyperinsulinaemia may mediate some of the effects of hypertension. Hyperuricaemia may represent the culmination a multimetabolic syndrome in which insulin-mediated renal haemodynamic abnormalities lead to hypertensive renal damage. Hyperuricemia is observed in hypertension may be due to a decrease in the renal blood flow and early nephrosclerosis.
Authors and Affiliations
B. Anil Kishore
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