Evaluation of Sperm Selection Technique Using Hyaluronic Acid Binding During ICSI; A Randomized Controlled Trial
Journal Title: Women's Health Science Journal - Year 2022, Vol 6, Issue 1
Abstract
Objective: To compare between Hyaluronan binding system for sperm selection for ICSI procedures (PICSI) and conventional morphology sperm selection. In vitro sperm selection for ICSI is important as it has a direct influence on the paternal contribution of preimplantation embryogenesis. Various laboratory tests were developed to assess the functions of the spermatozoa. Among them, only the tests for sperm DNA fragmentation, hyperactivation of the spermatozoa and the hyaluronan-binding ability are simple and fast. Study Design: A randomized controlled trial where three-hundred cases with male infertility were divided into 3 equal groups according to semen abnormality (oligo, astheno and teratozoospermia) then each group was randomly divided into 2 equal subgroups one underwent PICSI and the other underwent conventional ICSI. The outcomes were fertilization,high quality embryos and clinical pregnancy rate. Results: A significant difference was found in favor of PICSI as regards both high-quality embryos and clinical pregnancy rate in all 3 groups. A significant difference was also found in fertilization rate in favor of PICSI group in both oligozoospermia and teratozoospermia groups but not in asthenozoospermia group. Conclusion: PICSI technique provides better high-quality embryos, fertilization, and clinical pregnancy rates in cases with male factor infertility; however, further studies are needed to define specific criteria for performing PICSI taking into consideration both the expenses and time of the technique.
Authors and Affiliations
Hassan EA*, Behery MA, Ibrahim MM, Mohamed N and Abdelkawy AF
Keywords
Related Articles
- EP ID EP746523
- DOI 10.23880/whsj-16000164
- Views 43
- Downloads 0
The Availability and Effectiveness of Lactation Rooms Usage in Shopping Centers (Case Study in Metropolitan Jakarta)
Backgrounds: World Health Assembly stated that 41% of infants less than 6 months are exclusively breastfed, whereas the global rate target is at least 50% by 2025. Indonesia’s rate of exclusive breastfeeding was 68.7% in...
Comparison between Outcome of Assisted Reproductive Technique (Art) Cycles with and Without OCP Pretreatment in Infertile Women: A Randomized Clinical Trial
The objective of this randomized clinical trial was to assess the effect of pretreatment with oral contraceptive pill (OCP) on assisted reproductive technique outcomes in patient’s candidate for assisted reproductive tec...
Opinion: Menstruation One of the Oldest Non-Issues
The Planet Earth is a magical place where thousands of animal and plant species co-inhabit. It overflows with life. All living things share characteristics as movement, respiration, sensitivity, growth, reproduction, exc...
The Flagellate Transition- Serous Carcinoma Ovary
Serous ovarian tumours are engendered from Mullerian epithelium and denominate a segment of surface epithelial-stromal ovarian tumours. Serous ovarian carcinoma is classified as low grade tumefaction comprising of benign...
Carcinoma of Vagina in Women with Utero Vaginal Prolapse: Presentation of Two Cases and the Review of Literature
Primary vaginal cancer in women with utero vaginal prolapse is an uncommon entity. We report two women with longstanding third degree prolapse presented with ulcerated lesions. Both had vaginal hysterectomy and anterior...