EVALUATION OF THE ANTILEISHMANIAL EFFICACY OF MEDICINAL PLANT CHENOPODIUM ALBUM LINN. AGAINST EXPERIMENTAL VISCERAL LEISHMANIASIS.
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 7
Abstract
Objective: Visceral leishmaniasis is a neglected tropical disease resulting in death if not properly treated. The ongoing search for better leishmanicidal compounds has brought herbal drugs in to the limelight as safe and effective substitutes to conventional therapies which have various drawbacks. The current study was designed to evaluate the antileishmanial efficacy of medicinal plant Chenopodium album Linn. against L donovani in inbred BALB/c mice.Methods: Inbred BALB/c mice were infected intravenously with 1x107 Leishmania donovani promastigotes and Kept for 30 days. These animals were then treated with two doses (500mg/kg body wt. and 1000mg/kg body wt.) of methanolic extracts of C. album  orally for 7 days.Results: The animals treated with methanolic extracts of C. album, revealed a significant reduction in parasite load. These animals also showed a heightened DTH response and increased IgG2a as an indicator of protective Th1 type of immune response. Moreover, the liver and kidney function tests were found to be in the normal range.Conclusion: Hence the drug proved to be a good antileishmanial but further studies recommended before it is to be tested in higher animal models.Â
Authors and Affiliations
Rupinder Kaur, Jaspreet Kaur, Sukhbir Kaur, Jyoti Joshi
Keywords
Related Articles
- EP ID EP576245
- DOI -
- Views 88
- Downloads 0
A DE NOVO ASSEMBLY METHOD FOR SHORT SEQUENCE OF SOLID-SAGE READS RESPONSIBLE FOR WHEAT (TRITICUM AESTIVUM L.) LEAF RUST
Objective: Wheat leaf rust is one of the most widespread rust diseases caused by Puccinia triticina Eriks. De novo assembly of short sequence reads in order to understand the molecular phenomenon underlying wheat leaf ru...
PREPARATION AND CHARACTERIZATION OF CURCUMIN LOADED CASSAVA STARCH NANOPARTICLES WITH IMPROVED CELLULAR ABSORPTION
Objectives: The present study describes loading of curcumin onto cassava starch nanoparticles to improve its cellular absorption.Methods: Cassava starch nanoparticles were prepared by acid hydrolysis. A solution of curcu...
NOVEL PYRAZOLINES: SYNTHESIS AND EVALUATION OF THEIR DERIVATIVES WITH ANTICANCER AND ANTI-INFLAMMATORY ACTIVITIES
Objective: Synthesis of novel pyrazolines (P2-P4 & P7-P9) from the chalcones (C2-C10) obtained by condensing different aldehydes with 2-acetyl- 5-bromothiophene and evaluates them for in vitro anticancer and anti-inf...
VIRTUAL SCREENING AND ADMET ANALYSIS FOR IDENTIFICATION OF INHIBITORS AGAINST ACETYLCHOLINESTERASE ASSOCIATED WITH ALZHEIMER'S DISEASE
Objective: Alzheimer’s disease a progressive neurodegenerative disorder characterized by oxidative stress, amyloid β deposition and due to low level of neurotransmitter acetylcholine in the brain. the reduction of ace...
IMPACT OF tAI IN TRANSLATIONAL DYNAMICS OF HOMO SAPIENS GENES IN ESCHERICHIA COLI GENOME
Objective: Translation of mRNA to protein is a central biological process, and its regulation is vital for cell growth, development and differentiation. It is known that the tRNA molecules play a role of nearly 40% in th...