DETERMINATION OF ATORVASTATIN CALCIUM IN PURE AND ITS PHARMACEUTICAL FORMULATIONS USING IODINE IN ACETONITRILE BY UV-VISIBLE SPECTROPHOTOMETRIC METHOD
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Objective: A simple, sensitive and specific spectrophotometric method was developed for the determination of atorvastatin calcium (ATCa) in pure and its pharmaceutical formulations using iodine in acetonitrile.Methods: The method is based on the oxidation of atorvastatin calcium by iodine and formation triiodide (I3−) complex.Results: The formed complex was measured at 291 and 360 nm against the reagent blank prepared in the same manner. The optimum experimental parameters are selected. Beer’s law is valid within a concentration range of 0.5586-11.173 μg/ml. The relative standard deviation did not exceed 3.0% and regression analysis showed a good correlation coefficient (R2= 0.9995). The limit of detection (LOD) and the limit of quantification (LOQ) were to be 0.056 and 0.17 μg/ml, respectively.Conclusion: The developed method is applied for the determination of atorvastatin in pure and its commercial tablets without any interference from excipients (at lmax =291 & 360 nm), ezetimibe (EZE), fenofibrate (FEN) and aspirin (ASP) at lmax =360 nm with average recovery of 99.45 to 102.4%. The results obtained agree well with the contents stated on the labels.Â
Authors and Affiliations
Abdul Aziz Ramadan, Hasna Mandil, Jenan Sabouni
Keywords
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