EVALUATION OF THE ANTIOXIDANT AND ANTI-PROLIFERATIVE CHEMICAL CONSTITUENTS OF HYPTIS PECTINATA (LINN.) AERIAL INFUSION
Journal Title: International Journal of Pharmacognosy - Year 2018, Vol 5, Issue 1
Abstract
Objective: To evaluate the chemical composition, antioxidant and anti-proliferative activities of Hyptis pectinata aerial part aqueous extract (HYP). Method: Chemical profiling using high performance liquid chromatography with UV diode array detector (HPLC-UV-DAD), in-vitro antioxidant and anti-proliferative studies were done. Antioxidant and antiradical activities of HYP was investigated using 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and DPPH radical scavenging assay. Result: The present study revealed the several metabolites. HPLC analysis gave caffeic acid (13.92%), rutin (7.89%) and ferulic acid (5.44%) as some of the bioactive constituents. HYP showed antioxidant activity in both the DPPH and MTT assay. HYP exhibited antioxidant activity against DPPH and MTT from the first dilution at 10 mg/ml up to the ninth dilution at 0.08 mg/ml in a 2-fold dilution signifying presence of antioxidant compounds at those concentrations. At 1 mg/ml to 32 mg/ml, HYP dose-dependently and significantly (P < 0.001) inhibited Sorghum bicolor seed radicle growth over a period of 24-72 h compared to the negative control. Conclusion: Hyptis pectinata aerial part aqueous extract (HYP) possessed antioxidant and anti-proliferative activities, hence providing preliminary evidence for its use to treat cancer.
Authors and Affiliations
Samuel Ehiabhi Okhale et al.
Keywords
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