Evaluation of The Antiulcer Activity of Aqueous Seed Extract of Moringa Oleifera Lamarck (Moringaceae)
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 3
Abstract
Received 06 February 2018 Revised 26 February 2018 Accepted 06 March 2018 Published online 07 March 2018 Moringa oleifera Lam (Family: moringaceae) is a multipurpose tree with reported medicinal properties. The seeds are used traditionally to treat peptic ulcer. However, no pharmacological evidence to support the use of the aqueous seed extract of M. oleifera on peptic ulcer exists. The study therefore aimed at evaluating the antiulcer activity of the aqueous seed extract of M. oleifera. Isolated rabbit jejunum and guinea pig ileum were used to investigate its spasmolytic activity. The protective effect of the aqueous seed extract of M. oleifera was evaluated against pylorus ligated and indomethacin-induced ulcers in rats. The acute toxicity was determined by administering a single dose of 2,000 mg/kg orally to Wistar rats and observed 1 h post-dosing and once daily for 14 days. This dose did not produce mortality or acute signs of toxicity throughout the observation period. In the pylorus ligated studies, ulcer index and gastric juice volumes were not significantly different from the control, although, the extract at 500 mg/kg and omeprazole impacted positively on gastric juice pH and total acidity. However, all the doses used produced a significant (p < 0.01) inhibition of lesion in indomethacin induced-ulcer (40.84 - 45.02%) when compared with the control, but higher percentage inhibition was recorded with cimetidine (66.72%). On isolated tissue, the extract produced a relaxant effect alone, a slight inhibition of histaminergic contractions and no effect on Acetylcholine contractions. The results suggest that the extract lacks antisecretory properties but it is effective against indomethacin induced-ulcer in rats.
Authors and Affiliations
Fadila Lawal, Kamaluddeen Garba, Adamu B. Shuai, Basheer A. Z. Chedi
Keywords
Related Articles
- EP ID EP489449
- DOI 10.26538/tjnpr/v2i3.8
- Views 107
- Downloads 0
Aloe vera Prevents Radiation-Induced Dermatitis among the Black Population
Received 15 August 2018 Revised 15 September 2018 Accepted 20 September 2018 Published online 21 September 2018 Radiation-induced dermatitis is a major complication often encountered following radiotherapy, despite new...
Edible Mushrooms: As Functional Foods and Nutriceuticals
Mushrooms are macro-fungi that grow naturally on soil, agro wastes, on and around trees and are easily picked by hand. They occur in various sizes and shapes and may be edible or poisonous. Majority of mushrooms are ecto...
Fear and Anxiety Behaviour In Mice Was Attenuated Following Chronic Consumption of Musa paradisiaca L. (Musaceae)
Emotions are delicate phenomenon that can affect the whole livelihood, yet to control them physiologically is quite difficult perhaps owing to the paucity in connections between limbic system and neocortex. Many people h...
Hyptis suaveolens Extract Exhibits Larvicidal Activity Against Anopheles gambiae Larvae
Received 28 January 2018 Revised 08 May 2018 Accepted 08 May 2018 Published online 10 May 2018 Hyptis suaveolens (Lamiaceae) is traditionally used to repel insects. The aim of this study was to determine the larvicidal...
Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils
Received 30 December 2017 Revised 02 February 2018 Accepted 05 February 2018 Published online 07 February 2018 This work is aimed at producing an effective self-emulsifying nanoformulation of a combination of 9 antimic...