Evaluation of the bioactive potentialities of a diacetaldehyde terpenoid isolated from Curcuma caesia Roxb
Journal Title: The Journal of Phytopharmacology - Year 2013, Vol 2, Issue 4
Abstract
This paper represents evaluation of the bioactive potentialities of a diacetaldehyde terpenoid isolated from Curcuma caesia Roxb. The terpenoid was identified as (2Z,2'Z)-2,2'- (3aR,10aS)- 1,3,5,8,9,9- hexamethyl- 1,2,3,3a-tetrahydrobenzo [f] azulene- 4,10 (5H,8H,9H,10aH) - diylidene) diacetaldehyde. Assessment of its antitumour activity, antifungal activity and antibacterial activity was performed using brine shrimp cytotoxicity assay, agar cup method and disc diffusion assay respectively. The antitumour, antifungal as well as antibacterial activity was promising and it showed 25 mg/ml (LC 50 value), (25 mg/ml, 67 mg/ml, 39 mg/ml), (235 µg/ml, 257 µg/ml, 210 µg/ml, 322 µg/ml) value respectively. This study represents the first report of bioactive nature of (2Z,2'Z)-2,2'- (3aR,10aS)- 1,3,5,8,9,9- hexamethyl-1,2,3,3atetrahydrobenzo [f] azulene- 4,10 (5H,8H,9H,10aH)- diylidene) diacetaldehyde isolated from plants.
Authors and Affiliations
Arghya Ghosh, Parthadeb Ghosh, Padma Chatterjee
Keywords
Related Articles
- EP ID EP49518
- DOI -
- Views 276
- Downloads 0
Anti-inflammatory and analgesic potentials of Eleucine indica
The plant Eleucine indica has a long ethnobotanical history because of its use in the treatment painful and inflammatory conditions. This study was aimed at investigating the antiinflammatory and analgesic activities of...
Role of oxidative stress in various diseases: Relevance of dietary antioxidants
Oxidative stress plays important role in the pathophysiology of various diseases. Oxidative stress is caused in body due to an imbalance between the activities of endogenous pro-oxidative enzymes. Cellular antioxidants...
Phytochemical and free radical scavenging activity of Poorna chandrodayam chendooram (metallic herbal based drug)
Under most pathological conditions there is generation of reactive oxygen species and other free radicals. An increase in the antioxidant reserves of the organism can reduce oxidative stress and some of the plant-deriv...
Butanol soluble fractions of Cissus cornifolia methanolic leaf extract and behavioural effects in mice
Cissus cornifolia Baker - Planch (Family: Vitaceae) is used for various central nervous system disorders. The present study reported the sedative and central nervous depressant effects of fractions (butanol soluble port...
Quantifying phytophenols in Andrographis paniculata and Withania somnifera leaf extracts
Andrographis paniculata (Nilavembu) and Withania somnifera (Ashwagandha) are some of the commonly available herbs, used for treating a wide range of ailments in man and animals. Both the plants possesses a wide spectru...