Conformational Analysis of Therapeutic Proteins by Hydroxyl Radical Protein Footprinting

The online version of this article (doi:10.1208/s12248-012-9336-7) contains supplementary material, which is available to authorized users.

Controlled Release of Simvastatin from In situ Forming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells

Simvastatin (SIM), a drug commonly administered for the treatment of hypercholesterolemia, has been recently reported to induce bone regeneration/formation. In this study, we investigated the properties of hydrogel compo...

Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state

The deamidation kinetics of 7 model peptides (VYPNGA, VYGNGA, VFGNGA, VIGNGA, VGGNGA, VGPNGA, and VGYNGA) were studied at 70°C in pH 10 buffer solutions and at 70°C and 50% relative humidity in lyophilize...

Population pharmacokinetics: A memorial tribute to Lewis Sheiner

Biodegradable Microparticles Loaded with Doxorubicin and CpG ODN for In Situ Immunization Against Cancer

In situ immunization is based on the concept that it is possible to break immune tolerance by inducing tumor cell death in situ in a manner that provides antigen-presenting cells such as dendritic cells (DCs) with a wide...